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PMID: 389786 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Human Ia-like antigens in non-lymphoid organs.

Immunology ·Vol. 38 ·No. 2 ·1979-10-00 ·Pages 333-41

Koyama K, Fukunishi T, Barcos M, Tanigaki N, Pressman D

Abstract

Human Ia-like antigens in liver and kidney were shown by the immunofluorescence assay to be present mostly in the endothelial-mesenchymal cells of these organs. The parenchymal cells apparently contained no human Ia-like antigens. The antigens in liver and kidney were purified and shown to have the same subunit structure as human Ia-like antigens of cultured B-lymphoid cells. The human Ia-like antigens in non-lymphoid organs, not only in liver and kidney but also in testis, heart, muscle and brain, carried all the xenoantigenic characteristics of human Ia-like antigens expressed on lymphoid cells of B-cell lineage.

MeSH Terms
Antigen-Antibody Reactions B-Lymphocytes/immunology Electrophoresis, Polyacrylamide Gel Fluorescent Antibody Technique Histocompatibility Antigens/isolation & purification Humans Kidney/immunology Liver/immunology Mononuclear Phagocyte System/immunology
Chemicals
Histocompatibility Antigens
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Koyama K
Fukunishi T
Barcos M
Tanigaki N
Pressman D
References (20)
20 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1979-10-00
Pages
333-41
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1457930
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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