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PMID: 82605 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Immunological dissection of human Ia molecules.

The Journal of experimental medicine ·Vol. 148 ·No. 6 ·1978-12-01 ·Pages 1592-611

Tosi R, Tanigaki N, Centis D, Ferrara GB, Pressman D

Abstract

The immunochemical analysis of Daudi Ia molecules by a variety of alloantisera led to the recognition of at least three molecular species carrying different antigenic determinants: DRw6, DC-1, and DC-2. Genetic as well as structural evidence indicates that DRw6 and DC-1 molecules are controlled by separate, HLA-linked loci, rather than by alleles at the same locus. The alloantigenic determinants appear to be expressed on the small Ia subunit. DC-1 and DC-2 determinants discussed had not been defined by serological analysis at the population level, but were demonstrated to be present by immunochemical analysis at the molecular level.

MeSH Terms
Antigen-Antibody Reactions Antigens, Surface/analysis,genetics B-Lymphocytes/immunology Cell Line Complement Activation Cytotoxicity, Immunologic Epitopes HLA Antigens/genetics Humans Isoantigens/analysis Macromolecular Substances Major Histocompatibility Complex
Chemicals
Antigens, Surface Epitopes HLA Antigens Isoantigens Macromolecular Substances
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Tosi R
Tanigaki N
Centis D
Ferrara G B
Pressman D
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22 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.148.6.1592
Published
1978-12-01
Pages
1592-611
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2185093
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.148.6.1592 PMC Full Text View journal details
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