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PMID: 3900297 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immunohistological study of granulovacuolar degeneration using monoclonal antibodies to neurofilaments.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 48 ·No. 9 ·1985-09-00 ·Pages 924-6

Kahn J, Anderton BH, Probst A, Ulrich J, Esiri MM

Abstract

Neurons undergoing granulovacuolar degeneration have been examined in paraffin sections with three monoclonal antibodies to neurofilaments. Two of these antibodies (BF10, RT97) had been shown previously to react with neurofibrillary tangles. One of these antibodies (RT97) reacted with granular component of granulovacuolar degeneration. BF10 sometimes reacted with the surrounding neuronal cytoplasm. Granulovacuolar degeneration was also detected in a few cells of the anterior olfactory nucleus.

MeSH Terms
Alzheimer Disease/metabolism,pathology Antibodies, Monoclonal Brain/pathology Cytoplasmic Granules Cytoskeleton/metabolism Hippocampus/metabolism Humans Immunoenzyme Techniques Intermediate Filaments/metabolism Olfactory Bulb/metabolism Vacuoles
Chemicals
Antibodies, Monoclonal
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Kahn J
Anderton B H
Probst A
Ulrich J
Esiri M M
References (9)
9 references, click to expand
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Article Info
Journal
Journal of neurology, neurosurgery, and psychiatry
Abbr.
J Neurol Neurosurg Psychiatry
ISSN
0022-3050
DOI
10.1136/jnnp.48.9.924
Published
1985-09-00
Pages
924-6
Language
English
Region
England
NLM ID
2985191R
PMCID
PMC1028495
Subset
IM
External Links
PubMed source DOI: 10.1136/jnnp.48.9.924 PMC Full Text View journal details
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