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PMID: 3902803 Published · ppublish English Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

Common evolutionary origin of the phage T4 dam and host Escherichia coli dam DNA-adenine methyltransferase genes.

Journal of bacteriology ·Vol. 164 ·No. 2 ·1985-11-00 ·Pages 932-7

Hattman S, Wilkinson J, Swinton D, Schlagman S, Macdonald PM, Mosig G

Abstract

We compared the known DNA nucleotide and encoded amino acid sequences of the Escherichia coli and bacteriophage T4 dam (DNA-adenine methyltransferase) genes. Despite the absence of any DNA sequence homology, there were four regions (11 to 33 residues long) of amino acid sequence homology containing 45 to 64% identity. These results suggest that the genes for these two enzymes have a common evolutionary origin.

MeSH Terms
Adenine/analysis Amino Acid Sequence Base Composition Biological Evolution Codon DNA, Bacterial/analysis DNA, Viral/analysis Escherichia coli/enzymology,genetics Genes, Bacterial Genes, Viral Methyltransferases/genetics Sequence Homology, Nucleic Acid Site-Specific DNA-Methyltransferase (Adenine-Specific) T-Phages/enzymology,genetics Thymine/analysis
Chemicals
Codon DNA, Bacterial DNA, Viral Methyltransferases Site-Specific DNA-Methyltransferase (Adenine-Specific) Adenine Thymine
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Hattman S
Wilkinson J
Swinton D
Schlagman S
Macdonald P M
Mosig G
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28 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.164.2.932-937.1985
Published
1985-11-00
Pages
932-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC214344
Subset
IM
Grants
NIGMS NIH HHS · GM 13221 · United States
NIGMS NIH HHS · GM 29227 · United States
NIGMS NIH HHS · T-32 GM 07319 · United States
External Links
PubMed source DOI: 10.1128/jb.164.2.932-937.1985 PMC Full Text View journal details
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