Home LiteratureArticle Details
PMID: 3915538 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Activation of c-myb expression by phytohemagglutinin stimulation in normal human T lymphocytes.

Molecular and cellular biology ·Vol. 5 ·No. 10 ·1985-10-00 ·Pages 2874-7

Torelli G, Selleri L, Donelli A, Ferrari S, Emilia G, Venturelli D, Moretti L, Torelli U

Abstract

The expression of c-myb in normal human T lymphocytes directly derived from a normal subject and not adapted to continuous growth in culture was found to be markedly increased after phytohemagglutinin stimulation. In the same cells, the expression of c-myc mRNA is a much earlier event compared with the appearance of c-myb mRNA, which takes place soon after that of histone H3 mRNA. The increase in c-myb expression was not due to a particular T-lymphocyte subset, as shown by in situ hybridization assays.

MeSH Terms
Cells, Cultured Gene Expression Regulation Humans Lymphocyte Activation Nucleic Acid Hybridization Phytohemagglutinins/pharmacology Proto-Oncogene Proteins/genetics RNA, Messenger/genetics T-Lymphocytes/physiology
Chemicals
Phytohemagglutinins Proto-Oncogene Proteins RNA, Messenger
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Torelli G
Selleri L
Donelli A
Ferrari S
Emilia G
Venturelli D
Moretti L
Torelli U
References (35)
35 references, click to expand
  1. Transcripts from the cellular homologs of retroviral oncogenes: distribution among chicken tissues.
    Mol Cell Biol. 1982 Jun;2(6):617-24 PMID: 14582157
  2. Cell-cycle control of c-myc but not c-ras expression is lost following chemical transformation.
    Cell. 1984 Feb;36(2):241-7 PMID: 6692471
  3. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I.
    J Mol Biol. 1977 Jun 15;113(1):237-51 PMID: 881736
  4. Detection of viral sequences of low reiteration frequency by in situ hybridization.
    Proc Natl Acad Sci U S A. 1978 Dec;75(12):6125-9 PMID: 216014
  5. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues.
    Cell. 1980 Apr;19(4):947-58 PMID: 6247075
  6. Electrophoretic transfer of proteins and nucleic acids from slab gels to diazobenzyloxymethyl cellulose or nitrocellulose sheets.
    Anal Biochem. 1980 Mar 1;102(2):459-71 PMID: 7425302
  7. DNA methylation and gene function.
    Science. 1980 Nov 7;210(4470):604-10 PMID: 6254144
  8. Expression of endogenous avian myeloblastosis virus information in different chicken cells.
    J Virol. 1980 Oct;36(1):162-70 PMID: 6255203
  9. Vertebrate DNAs contain nucleotide sequences related to the transforming gene of avian myeloblastosis virus.
    J Virol. 1981 Nov;40(2):450-5 PMID: 6275098
  10. Proposal for naming host cell-derived inserts in retrovirus genomes.
    J Virol. 1981 Dec;40(3):953-7 PMID: 7321107
  11. Sequence complexity and diversity of polyadenylated RNA molecules of human normal resting, PHA-stimulated and leukemic lymphocytes.
    Nucleic Acids Res. 1981 Dec 21;9(24):7013-32 PMID: 6174950
  12. Differential expression of the amv gene in human hematopoietic cells.
    Proc Natl Acad Sci U S A. 1982 Apr;79(7):2194-8 PMID: 6954533
  13. Cloning and characterization of different human sequences related to the onc gene (v-myc) of avian myelocytomatosis virus (MC29).
    Proc Natl Acad Sci U S A. 1982 Nov;79(21):6497-501 PMID: 6292905
  14. DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas.
    Science. 1983 May 20;220(4599):795-8 PMID: 6687762
  15. Transcription of hematopoietic-associated oncogenes in childhood leukemia.
    Cancer Res. 1983 Aug;43(8):3912-8 PMID: 6861153
  16. Retroviral transforming genes in normal cells?
    Nature. 1983 Jul 21-27;304(5923):219-26 PMID: 6346107
  17. Differential expression of c-erbB, c-myc and c-myb oncogene loci in human lymphomas and leukemias.
    Int J Cancer. 1983 Aug 15;32(2):185-91 PMID: 6603429
  18. Structural organization and expression of human DNA sequences related to the transforming gene of avian myeloblastosis virus.
    Proc Natl Acad Sci U S A. 1983 Dec;80(24):7385-9 PMID: 6324165
  19. Expression of cellular oncogenes in human malignancies.
    Science. 1984 Apr 20;224(4646):256-62 PMID: 6538699
  20. Amplification of the c-myb oncogene in a case of human acute myelogenous leukemia.
    Science. 1984 Jun 8;224(4653):1117-21 PMID: 6585957
  21. Expression of myb, myc and fos proto-oncogenes during the differentiation of a murine myeloid leukaemia.
    Nature. 1984 Jul 19-25;310(5974):249-51 PMID: 6205276
  22. Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma.
    Proc Natl Acad Sci U S A. 1984 Jul;81(14):4534-8 PMID: 6589609
  23. Expression of histone genes in a G1-specific temperature-sensitive mutant of the cell cycle.
    Biochemistry. 1984 Jul 31;23(16):3731-5 PMID: 6477892
  24. Activation of the c-myb locus by viral insertional mutagenesis in plasmacytoid lymphosarcomas.
    Science. 1984 Nov 30;226(4678):1077-80 PMID: 6093260
  25. Autoimmunity and increased c-myb transcription.
    Science. 1984 Nov 30;226(4678):1087-9 PMID: 6494925
  26. Oncogene expression in human leukemia.
    Blood. 1984 Dec;64(6):1234-9 PMID: 6208953
  27. Expression of a proto-oncogene (proto-myb) in hemopoietic tissues of mice.
    Mol Cell Biol. 1984 Jul;4(7):1206-12 PMID: 6504046
  28. Expression of the c-myb oncogene in human small cell lung carcinoma.
    Cancer Res. 1985 Jan;45(1):272-5 PMID: 2578097
  29. Use of a cell cycle mutant to delineate the critical period for the control of histone mRNA levels in the mammalian cell cycle.
    Mol Cell Biol. 1984 Nov;4(11):2364-9 PMID: 6513920
  30. Expression of human c-fes onc-gene occurs at detectable levels in myeloid but not in lymphoid cell populations.
    Br J Haematol. 1985 Jan;59(1):21-5 PMID: 3855647
  31. Study of the levels of expression of two oncogenes, c-myc and c-myb, in acute and chronic leukemias of both lymphoid and myeloid lineage.
    Leuk Res. 1985;9(7):833-42 PMID: 3860696
  32. The cellular oncogenes c-myc, c-myb and c-erb are transcribed in defined types of avian hematopoietic cells.
    Exp Cell Res. 1983 Nov;149(1):151-62 PMID: 6196212
  33. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor.
    Cell. 1983 Dec;35(3 Pt 2):603-10 PMID: 6606489
  34. Early decline in c-myb oncogene expression in the differentiation of human myeloblastic leukemia (ML-1) cells induced with 12-O-tetradecanoylphorbol-13-acetate.
    Cancer Res. 1984 Feb;44(2):442-6 PMID: 6198073
  35. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.5.10.2874-2877.1985
Published
1985-10-00
Pages
2874-7
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC367031
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.5.10.2874-2877.1985 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2