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PMID: 3937758 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes.

Diabetologia ·Vol. 28 ·No. 12 ·1985-12-00 ·Pages 891-4

Sheehy MJ, Rowe JR, Fuller TC, Yunis EJ, Gabbay KH

Abstract

We have been using human T-lymphocyte clones specifically sensitized to detect leucocyte antigens of Type 1 (insulin-dependent) diabetic patients in the hope of detecting novel HLA antigens associated with Type 1 diabetes. We previously described two such clones which define a new class II HLA antigen, Boston-1 (BO1). BO1 is found mainly on cells of persons with particular HLA-DR antigens and, of potential significance for diabetes, BO1 identifies a distinctive subset of DR3 haplotypes. We report here that BO1+ DR3 haplotypes are overrepresented in Type 1 diabetes. That is, significantly more of the DR3-positive subjects are BO1-positive in the patient group (31%) than in the control group (8%), suggesting that a diabetes-susceptibility gene may be more common on the BO1+ than on the BO1- DR3 haplotypes. Alternative interpretations are also discussed.

MeSH Terms
Alleles Cell Line Clone Cells Diabetes Mellitus, Type 1/immunology Genes, MHC Class II Genetic Linkage HLA-DR3 Antigen Histocompatibility Antigens Class II/analysis Humans T-Lymphocytes/immunology
Chemicals
HLA-DR3 Antigen Histocompatibility Antigens Class II
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Sheehy M J
Rowe J R
Fuller T C
Yunis E J
Gabbay K H
References (19)
19 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00703131
Published
1985-12-00
Pages
891-4
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
Grants
NIADDK NIH HHS · AM-34504 · United States
NCI NIH HHS · CA-20531 · United States
NHLBI NIH HHS · HL-34999 (HL-20539) · United States
External Links
PubMed source DOI: 10.1007/BF00703131 View journal details
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