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PMID: 396882 Published · ppublish English Journal Article

Mutagenicity of 5,6-dimethoxysterigmatocystin, a metabolite from Aspergillus multicolor, in the Salmonella/microsome system.

Applied and environmental microbiology ·Vol. 38 ·No. 5 ·1979-11-00 ·Pages 1015-7

Wehner FC, Thiel PG, Vleggaar R

Abstract

The natural sterigmatocystin derivative, 5,6-dimethoxysterigmatocystin, was found to be a mutagen for Salmonella typhimurium strains TA98 and TA100 after metabolic activation in a mammalian microsome system.

MeSH Terms
Animals Aspergillus/metabolism Biotransformation Chemical Phenomena Chemistry Microsomes, Liver/metabolism Mutagens/biosynthesis Rats Salmonella typhimurium/drug effects Sterigmatocystin/analogs & derivatives,biosynthesis,pharmacology Xanthenes/pharmacology
Chemicals
Mutagens Xanthenes Sterigmatocystin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wehner F C
Thiel P G
Vleggaar R
References (12)
12 references, click to expand
  1. The production of chaetoglobosins, sterigmatocystin, O-methylsterigmatocystin, and chaetocin by Chaetomium spp. and related fungi.
    Can J Microbiol. 1979 Feb;25(2):170-7 PMID: 436014
  2. Production of sterigmatocystin by Aspergillus versicolor and Bipolaris sorokiniana on semisynthetic liquid and solid media.
    Appl Environ Microbiol. 1976 Aug;32(2):206-8 PMID: 970940
  3. Aflatoxin B1-2,3-oxide as a probable intermediate in the covalent binding of aflatoxins B1 and B2 to rat liver DNA and ribosomal RNA in vivo.
    Cancer Res. 1977 Jan;37(1):172-81 PMID: 187331
  4. Mutagenicity to Salmonella typhimurium of some Aspergillus and Penicillium mycotoxins.
    Mutat Res. 1978 Nov;58(2-3):193-203 PMID: 370570
  5. Mutagenicity of carcinogenic mycotoxins in Salmonella typhimurium.
    Cancer Res. 1978 Mar;38(3):536-42 PMID: 342092
  6. Mutagenicity of fungal metabolites related to aflatoxin biosynthesis.
    Mutat Res. 1977 Sep;44(3):447-50 PMID: 333283
  7. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos.
    Appl Microbiol. 1975 Oct;30(4):589-91 PMID: 811164
  8. DNA-attacking ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis.
    Cancer Res. 1976 Feb;36(2 Pt 1):445-51 PMID: 816461
  9. The reactivity and carcinogenicity of aflatoxin B1-2,3-dichloride, a model for the putative 2,3-oxide metabolite of aflatoxin B1.
    Cancer Res. 1975 Dec;35(12):3811-23 PMID: 1104159
  10. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
    Mutat Res. 1975 Dec;31(6):347-64 PMID: 768755
  11. Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential.
    Proc Natl Acad Sci U S A. 1976 Jul;73(7):2241-4 PMID: 781672
  12. Mycotoxins in Aspergillus.
    Mycopathol Mycol Appl. 1971 Feb 19;43(2):137-52 PMID: 5102221
Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
0099-2240
DOI
10.1128/aem.38.5.1015-1017.1979
Published
1979-11-00
Pages
1015-7
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC243623
Subset
IM
External Links
PubMed source DOI: 10.1128/aem.38.5.1015-1017.1979 PMC Full Text View journal details
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