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PMID: 3972439 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Anaphylactic-like reaction of small intestinal epithelium in parasitized guinea-pigs.

Immunology ·Vol. 54 ·No. 3 ·1985-03-00 ·Pages 573-9

Russell DA, Castro GA

Abstract

Antigens derived from Trichinella spiralis were used to challenge, in vitro, sensitized jejunum from infected guinea-pigs while monitoring ion transport properties of the tissue. Antigen challenge resulted in dose-dependent increases in trans-epithelial electrical potential difference and short circuit current. Both antigen-stimulated electrical alterations and Schultz-Dale contractions were demonstrated in small intestinal tissue after the passive transfer of immune serum containing anti-trichinella homocytotropic antibodies.

MeSH Terms
Anaphylaxis/immunology Animals Antigens, Helminth/immunology Dose-Response Relationship, Immunologic Electric Conductivity Guinea Pigs Hypersensitivity, Immediate Immune Sera/immunology Immunization, Passive Intestinal Mucosa/immunology,physiopathology Intestine, Small/immunology Male Membrane Potentials Ovalbumin/immunology Passive Cutaneous Anaphylaxis Trichinellosis/immunology,physiopathology
Chemicals
Antigens, Helminth Immune Sera Ovalbumin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Russell D A
Castro G A
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23 references, click to expand
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Article Info
Journal
Immunology
Abbr.
Immunology
ISSN
0019-2805
Published
1985-03-00
Pages
573-9
Language
English
Region
England
NLM ID
0374672
PMCID
PMC1453515
Subset
IM
Grants
NIAID NIH HHS · AI-11361 · United States
NIADDK NIH HHS · AM-07408 · United States
NCRR NIH HHS · K01-RR00026 · United States
External Links
PubMed source PMC Full Text View journal details
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