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PMID: 401507 Published · ppublish English Journal Article

Inhibition of adherence of Neisseria gonorrhoeae by human genital secretions.

The Journal of clinical investigation ·Vol. 59 ·No. 1 ·1977-01-00 ·Pages 117-24

Tramont EC

Abstract

Local genital antibodies to the infecting strains of Neisseria gonorrhoeae were demonstrated by indirect immunofluorescence (binding antibody) and by their ability to inhibit the attachment of gonococci to epithelial cells (functional antibody). Both IgG and IgA classes of immunoglobulin were involved, and the IgA component were primarily of a secreting (11S) nature. The ability of local genital antibody to inhibit attachment appears to persist for at least a short period of time and to be relatively strain specific.

MeSH Terms
Antibodies, Bacterial Cell Adhesion Epithelium/physiology Female Fluorescent Antibody Technique Genitalia/immunology Humans Immunoglobulin A/analysis Immunoglobulin G/analysis Male Neisseria gonorrhoeae/immunology Vagina/immunology,physiology
Chemicals
Antibodies, Bacterial Immunoglobulin A Immunoglobulin G
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Tramont E C
References (30)
30 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI108608
Published
1977-01-00
Pages
117-24
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC333338
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI108608 PMC Full Text View journal details
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