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PMID: 405970 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14.

Biochemical genetics ·Vol. 15 ·No. 3-4 ·1977-04-00 ·Pages 347-55

Womack JE, Davisson MT, Eicher EM, Kendall DA

Abstract

A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was established by backcross experiments in which alleles at Np-1 and Robertsonian translocations were segregating. Es-10 was shown to be linked to Np-1, and the following genetic map of Chr 14 was constructed: centromere-(8.9 +/- 4.0 cM)-[Np-1, Wc]-(10.2 +/- 1.9 cM)-Es-10-(15.5 +/- 3.7 cM)-s. The homologous human loci, NP and ES-D, are not linked.

MeSH Terms

Alleles Animals Chromosome Mapping Chromosomes Crosses, Genetic Esterases/blood Female Genotype Isoenzymes/blood Male Mice Mice, Inbred Strains Pentosyltransferases/blood Purine-Nucleoside Phosphorylase/blood Recombination, Genetic Species Specificity

Chemicals

Isoenzymes Pentosyltransferases Purine-Nucleoside Phosphorylase Esterases

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Womack J E

Davisson M T

Eicher E M

Kendall D A

References (13)

13 references, click to expand

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Segregation of esterase-D and adenine phosphoribosyl transferase in somatic cell hybrids: gene linkage or chromosome association?
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Comparative autosomal linkage in mammals: genetics of esterases in Mus musculus and Rattus norvegicus.
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Esterase D: a new human polymorphism.
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Inherited variants of human nucleoside phosphorylase.
Ann Hum Genet. 1971 May;34(4):395-408 PMID: 5579411
A preliminary genetic interpretation of the esterase isozymes of human tissues.
Ann Hum Genet. 1975 Jul;39(1):1-20 PMID: 1180483
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Chromosome assignment of some human enzyme loci: mitochondrial malate dehydrogenase to 7, mannosephosphate isomerase and pyruvate kinase to 15 and probably, esterase D to 13.
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Article Info

Journal

Biochemical genetics

Abbr.

Biochem Genet

ISSN

0006-2928

DOI

10.1007/BF00484465

Published

1977-04-00

Pages

347-55

Language

English

Region

United States

NLM ID

0126611

Subset

External Links

PubMed source DOI: 10.1007/BF00484465 View journal details

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Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14.

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