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PMID: 4073866 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents.

Antimicrobial agents and chemotherapy ·Vol. 28 ·No. 3 ·1985-09-00 ·Pages 442-5

Morris JG, Tenney JH, Drusano GL

Abstract

The in vitro activity of norfloxacin and six other antimicrobial agents was tested against 93 vibrio strains representing the currently described pathogenic Vibrio species. Norfloxacin had excellent activity against all species, with the following MICs for 90% of the strains: 0.016 micrograms/ml for Vibrio cholerae (including tetracycline-resistant V. cholerae O1 strains), 0.25 micrograms/ml for V. parahaemolyticus, and 0.063 micrograms/ml for V. vulnificus.

MeSH Terms

Ampicillin/pharmacology Chloramphenicol/pharmacology Gentamicins/pharmacology In Vitro Techniques Microbial Sensitivity Tests Nalidixic Acid/pharmacology Norfloxacin/pharmacology Sulfamethoxazole/pharmacology Tetracycline/pharmacology Trimethoprim/pharmacology Vibrio/drug effects

Chemicals

Gentamicins Nalidixic Acid Chloramphenicol Ampicillin Trimethoprim Tetracycline Sulfamethoxazole Norfloxacin

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Morris J G

Tenney J H

Drusano G L

References (12)

12 references, click to expand

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Endemic cholera in rural Bangladesh, 1966-1980.
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Plasmid-borne multiple drug resistance in Vibrio cholerae serogroup O1, biotype El Tor: evidence for a point-source outbreak in Bangladesh.
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Ann Intern Med. 1983 Mar;98(3):360-5 PMID: 6830079
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Comparative in vitro activities of ten antimicrobial agents against bacterial enteropathogens.
Antimicrob Agents Chemother. 1983 Oct;24(4):509-13 PMID: 6651278
The pharmacokinetics and tissue penetration of norfloxacin.
J Antimicrob Chemother. 1984 Jan;13(1):87-92 PMID: 6230344
Comparative in vitro activity of ciprofloxacin against Campylobacter spp. and other bacterial enteric pathogens.
Antimicrob Agents Chemother. 1984 Apr;25(4):504-6 PMID: 6732220
Recovery of norfloxacin in feces after administration of a single oral dose to human volunteers.
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In vitro antibacterial activity of norfloxacin (MK-0366, AM-715) and other agents against gastrointestinal tract pathogens.
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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.28.3.442

Published

1985-09-00

Pages

442-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC180271

Subset

External Links

PubMed source DOI: 10.1128/AAC.28.3.442 PMC Full Text View journal details

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In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents.

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