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PMID: 40848 Published · ppublish English Journal Article

Prostaglandin synthetase activity in acute ulcerative colitis: effects of treatment with sulphasalazine, codeine phosphate and prednisolone.

Gut ·Vol. 20 ·No. 9 ·1979-09-00 ·Pages 802-5

Smith PR, Dawson DJ, Swan CH

Abstract

Prostaglandin synthetase activity in rectal biopsy specimens from patients with ulcerative colitis has been shown to fall on treatment with sulphasalazine, local steroids, and codeine phosphate. In vitro studies have shown that sulphasalazine is an inhibitor of prostaglandin synthetase, although less potent than indomethacin, whereas prednisolone and codeine phosphate were inactive. It is suggested that the therapeutic action of sulphasalazine may be related in part to its action in inhibiting prostaglandin biosynthesis.

MeSH Terms
Codeine/therapeutic use Colitis, Ulcerative/drug therapy,enzymology Humans In Vitro Techniques Indomethacin/pharmacology Intestinal Mucosa/drug effects,enzymology Prednisolone/therapeutic use Prostaglandin-Endoperoxide Synthases/metabolism Sulfasalazine/pharmacology,therapeutic use
Chemicals
Sulfasalazine Prednisolone Prostaglandin-Endoperoxide Synthases Codeine Indomethacin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Smith P R
Dawson D J
Swan C H
References (24)
24 references, click to expand
  1. Determination of prostaglandin synthetase activity in rectal biopsy material and its significance in colonic disease.
    Gut. 1978 Oct;19(10):875-7 PMID: 101423
  2. Hydrocortisone inhibits prostaglandin production by mouse fibrosarcoma cells.
    Nature. 1975 Dec 25;258(5537):739-41 PMID: 1207759
  3. PROSTAGLANDINS AND RELATED FACTORS: XIX. THIN-LAYER CHROMATOGRAPHY OF PROSTAGLANDINS.
    J Lipid Res. 1964 Jan;5:117-20 PMID: 14173316
  4. Inhibition of release of prostaglandins as an explanation of some of the actions of anti-inflammatory corticosteroids.
    Nature. 1975 Mar 27;254(5498):308-11 PMID: 163980
  5. The metabolism of salicylazosulphapyridine in ulcerative colitis. I. The relationship between metabolites and the response to treatment in inpatients.
    Gut. 1973 Aug;14(8):631-41 PMID: 4147555
  6. Prostaglandin secretion by medullary carcinoma of the thyroid. A possible cause of the associated idarrhoea.
    Lancet. 1968 Jan 6;1(7532):22-3 PMID: 4169067
  7. Prostaglandins in amine-peptide-secreting tumours.
    Lancet. 1968 Nov 16;2(7577):1053-4 PMID: 4176865
  8. Effect of oral prostaglandin E1 on intestinal transit in man.
    Lancet. 1969 Mar 29;1(7596):648-51 PMID: 4179885
  9. Release of prostaglandin by mitogen- and antigen-stimulated leukocytes in culture.
    J Clin Invest. 1974 Aug;54(2):378-86 PMID: 4367890
  10. Effects of anti-inflammatory drugs on prostaglandin biosynthesis.
    Nat New Biol. 1972 Jul 26;238(82):104-6 PMID: 4505422
  11. Prostaglandins and the gastrointestinal tract.
    Gut. 1973 May;14(5):402-17 PMID: 4577412
  12. Effect of non-steroid anti-inflammatory drugs on prostaglandin biosynthesis by skin.
    Br J Dermatol. 1973 Jan;88(1):47-50 PMID: 4686542
  13. Inhibition of prostaglandin biosynthesis by sulphasalazine and its metabolites.
    Prostaglandins. 1976 Feb;11(2):219-25 PMID: 4854
  14. The effect of intravenous prostaglandin F 2 on small intestinal function.
    Gut. 1972 Oct;13(10):854 PMID: 5087118
  15. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
    Nat New Biol. 1971 Jun 23;231(25):232-5 PMID: 5284360
  16. Treatment of radiation-induced gastrointestinal distress with acetylsalicylate.
    Lancet. 1975 Nov 15;2(7942):942-3 PMID: 53429
  17. Letter: Prostaglandins, ulcerative colitis, and sulphasalazine.
    Lancet. 1975 Nov 15;2(7942):988 PMID: 53480
  18. Effect of orally administered prostaglandin E1 on gastric secretion and gastrointestinal motility in man.
    Gut. 1968 Dec;9(6):655-8 PMID: 5717966
  19. Increased prostaglandin production in ulcerative colitis.
    Lancet. 1977 Jul 9;2(8028):98 PMID: 69189
  20. An experiment to determine the active therapeutic moiety of sulphasalazine.
    Lancet. 1977 Oct 29;2(8044):892-5 PMID: 72239
  21. Venous prostaglandin-like activity in diarrhoeal states.
    Gut. 1978 Nov;19(11):1057-8 PMID: 730074
  22. Prostaglandin-synthesis inhibitors in prophylaxis of food intolerance.
    Lancet. 1978 Apr 29;1(8070):906-8 PMID: 76847
  23. The mode of action of aspirin and similar compounds.
    J Allergy Clin Immunol. 1976 Dec;58(6):691-712 PMID: 791988
  24. Stimulation of prostaglandin biosynthesis by drugs: effects in vitro of some drugs affecting gut function.
    Br J Pharmacol. 1976 Oct;58(2):193-9 PMID: 824000
Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.20.9.802
Published
1979-09-00
Pages
802-5
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1412641
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.20.9.802 PMC Full Text View journal details
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