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PMID: 409683 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Impairment of cell-mediated immune responses by infection with Mycobacterium lepraemurium.

Infection and immunity ·Vol. 18 ·No. 1 ·1977-10-00 ·Pages 157-64

Bullock WE, Evans PE, Filomeno AR

Abstract

The effect of chronic infection with Mycobacterium lepraemurium upon cell-mediated immune responses was studied in Lewis rats. Rats infected for 40 to 175 days were completely protected from attempted induction of experimental adjuvant disease, and the severity of experimental allergic encephalomyelitis in leprous rats was markedly attenuated. Full manifestations of each autoimmune disease were expressed in littermate control groups. Skin homograft rejection by infected rats was significantly impaired (P less than 0.001) as was the delayed-type hypersensitivity response to sheep erythrocytes (P less than 0.02). It is suggested that chronic infection with M. lepraemurium exerts a nonspecific inhibitory effect on cell-mediated immunity by perturbation of normal lymphocyte recirculation and by induction of immuno-suppressor cell activity.

MeSH Terms
Animals Antibody Formation Arthritis, Experimental/immunology Encephalomyelitis, Autoimmune, Experimental/immunology Erythrocytes/immunology Graft Survival Hemagglutinins Hypersensitivity, Delayed/immunology Immunity, Cellular Immunosuppression Therapy Inflammation/immunology Male Mycobacterium Infections/immunology,microbiology Mycobacterium lepraemurium Mycobacterium tuberculosis/immunology Rats Rats, Inbred Lew
Chemicals
Hemagglutinins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bullock W E
Evans P E
Filomeno A R
References (33)
33 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.18.1.157-164.1977
Published
1977-10-00
Pages
157-64
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421208
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.18.1.157-164.1977 PMC Full Text View journal details
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