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PMID: 4131513 Published · ppublish English Journal Article

Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen.

The Journal of experimental medicine ·Vol. 139 ·No. 4 ·1974-04-01 ·Pages 925-42

Yoshiki T, Mellors RC, Hardy WD, Fleissner E

Abstract

The indirect membrane immunofluorescence test and the absorption analysis of rabbit anti-FeLV, rabbit anti-FeLVp 30, and rabbit anti-MuLVp 30 antisera yielded the following conclusions. An antigen shared by mammalian (murine and feline) C-type RNA leukemia and sarcoma viruses was detected on the surface of cells infected or transformed by C-type viruses. The antigen was characterized as membrane-bound gs antigen bearing two determinants, membrane-bound gs-1, intraspecies-specific antigenic determinant, and membrane-bound gs-3, interspecies-specific antigenic determinant. Membrane-bound gs antigen was located on the cell surface, frequently near the site of virus budding but not on the envelope of murine C-type RNA virus.

MeSH Terms
Animals Antibodies, Viral/analysis Antigens, Neoplasm/analysis Antigens, Viral/analysis Cell Line Cell Membrane/immunology Cell Transformation, Neoplastic Cross Reactions Epitopes Fluorescent Antibody Technique Immune Sera Leukemia Virus, Feline/immunology Leukemia Virus, Murine/immunology Leukemia, Experimental/immunology Mice Microscopy, Electron Neoplasms, Experimental/immunology Retroviridae/immunology Viral Proteins/analysis
Chemicals
Antibodies, Viral Antigens, Neoplasm Antigens, Viral Epitopes Immune Sera Viral Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Yoshiki T
Mellors R C
Hardy W D
Fleissner E
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27 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.139.4.925
Published
1974-04-01
Pages
925-42
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2139571
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.139.4.925 PMC Full Text View journal details
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