Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice.

The Journal of experimental medicine ·Vol. 135 ·No. 2 ·1972-02-01 ·Pages 429-36

Rowe WP, Pincus T

Abstract

Quantitative studies were made of the organ distribution of murine leukemia virus in AKR mice of various ages. Infectious virus first appeared shortly before or after birth and was continuously present in all mice thereafter. Highest infectivity titers were found in uterus and bone, with spleen slightly lower. Virus titers in normal thymus were relatively low, but increased significantly with the development of thymic lymphoma. The level of viremia decreased after the 1st month of life, but increased sharply in lymphomatous mice.

MeSH Terms

Aging Animals Animals, Newborn Bone and Bones/microbiology Cells, Cultured Embryo, Mammalian Female Gestational Age Leukemia/veterinary Leukemia Virus, Murine/isolation & purification,pathogenicity Leukemia, Experimental/etiology Lymphoma/microbiology Mice Mice, Inbred Strains Organ Specificity Pregnancy Rodent Diseases/microbiology Spleen/microbiology Thymus Gland/microbiology Thymus Neoplasms/microbiology Uterus/microbiology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Rowe W P

Pincus T

References (9)

9 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.135.2.429

Published

1972-02-01

Pages

429-36

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180520

Subset

External Links

PubMed source DOI: 10.1084/jem.135.2.429 PMC Full Text View journal details

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