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PMID: 413843 Published · ppublish English Journal Article

Aminoglycoside cross-resistance patterns of gentamicin-resistant bacteria.

Journal of clinical pathology ·Vol. 30 ·No. 8 ·1977-08-00 ·Pages 738-44

Houang ET, Greenwood D

Abstract

Ten strains each of Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were habituated to gentamicin by serial passage in antibiotic containing medium. Complete cross-resistance to streptomycin, neomycin, kanamycin, and tobramycin in a linear proportional fashion was demonstrated at all stages of habituation. Most strains of Staph. aureus and Ps. aeruginosa showed a greater increase in resistance to gentamicin than to the other three aminoglycosides. E. coli required more transfers to reach the same degree of resistance than did the other two species. Reversion to greater susceptibility to gentamicin took place after serial passage on antibiotic-free media. 'Wild' gentamicin-resistant strains showed no such proportionality of resistance to kanamycin, neomycin, or streptomycin. But many of these strains showed a proportional increase in resistance to tobramycin.

MeSH Terms
Aminoglycosides/pharmacology Bacteria/drug effects Drug Resistance, Microbial Escherichia coli/drug effects Gentamicins/pharmacology Pseudomonas aeruginosa/drug effects Staphylococcus aureus/drug effects
Chemicals
Aminoglycosides Gentamicins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Houang E T
Greenwood D
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21 references, click to expand
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.30.8.738
Published
1977-08-00
Pages
738-44
Language
English
Region
England
NLM ID
0376601
PMCID
PMC476537
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.30.8.738 PMC Full Text View journal details
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