Activation of transcription of hut DNA by glutamine synthetase.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 1 ·1974-01-00 ·Pages 225-9

Tyler B, Deleo AB, Magasanik B

Abstract

The correct transcription of the hut (histidine utilization) operon DNA of Salmonella typhimurium requires activation either by 3':5'-cyclic adenosine monophosphate and catabolite-activating protein or by nonadenylylated glutamine synthetase (EC 6.3.1.2.). Thus, glutamine synthetase plays a regulatory role distinct from its enzymatic function.

MeSH Terms

Bacterial Proteins/pharmacology Chromosome Mapping Chromosomes, Bacterial Coliphages Cyclic AMP/pharmacology DNA, Bacterial/metabolism DNA, Viral/metabolism DNA-Directed RNA Polymerases/metabolism Escherichia coli/enzymology Genes Glutamate-Ammonia Ligase/pharmacology Histidine/metabolism Nucleic Acid Hybridization Operon RNA, Viral/biosynthesis,metabolism Salmonella typhimurium/metabolism Transcription, Genetic/drug effects Transduction, Genetic

Chemicals

Bacterial Proteins DNA, Bacterial DNA, Viral RNA, Viral Histidine Cyclic AMP DNA-Directed RNA Polymerases Glutamate-Ammonia Ligase

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Tyler B

Deleo A B

Magasanik B

References (18)

18 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.71.1.225

Published

1974-01-00

Pages

225-9

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC387970

Subset

External Links

PubMed source DOI: 10.1073/pnas.71.1.225 PMC Full Text View journal details

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Activation of transcription of hut DNA by glutamine synthetase.

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