Nature and self-regulated synthesis of the repressor of the hut operons in Salmonella typhimurium.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 7 ·1971-07-00 ·Pages 1493-7

Smith GR, Magasanik B

Abstract

The enzymes mediating histidine utilization, coded by the hut genes, in Salmonella typhimurium are synthesized from two closely-linked operons. Results presented in this paper show that these operons are regulated by a single repressor protein. The hutC gene, coding for this repressor, is part of one of the operons. Since this same operon is sensitive to the repressor, the repressor apparently represses its own synthesis.

MeSH Terms

Acrylates Aminohydrolases/biosynthesis Bacterial Proteins/biosynthesis,pharmacology Coliphages Enzyme Induction Escherichia coli Genes, Regulator/drug effects Genetics, Microbial Glutamates Histidine/metabolism Hydro-Lyases/biosynthesis Hydrolases/biosynthesis Imidazoles Lyases/analysis,biosynthesis Mutation Operon Oxidoreductases/biosynthesis Salmonella typhimurium/enzymology Transduction, Genetic

Chemicals

Acrylates Bacterial Proteins Glutamates Imidazoles Histidine Oxidoreductases Hydrolases Aminohydrolases Lyases Hydro-Lyases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Smith G R

Magasanik B

References (11)

11 references, click to expand

The two operons of the histidine utilization system in Salmonella typhimurium.
J Biol Chem. 1971 May 25;246(10):3330-41 PMID: 4930060
The antirepressor: a new element in the regulation of protein synthesis.
Nature. 1970 Apr 4;226(5240):31-2 PMID: 5434365
Sense and nonsense in the genetic code. Three exceptional triplets can serve as both chain-terminating signals and amino acid codons.
Science. 1968 Apr 12;160(3824):149-59 PMID: 4868223
Regulation of repressor expression in lambda.
Proc Natl Acad Sci U S A. 1970 Jul;66(3):855-62 PMID: 5269249
ISOLATION OF A PROTEIN SPECIFIED BY A REGULATOR GENE.
J Mol Biol. 1964 Jun;8:841-52 PMID: 14192076
Location of the phage lambda gene responsible for turning off lambda-exonuclease synthesis.
Virology. 1970 Jan;40(1):65-71 PMID: 5411194
Genetic and metabolic control of enzymes responsible for histidine degradation in Salmonella typhimurium. 4-imidazolone-5-propionate amidohydrolase and N-formimino-L-glutamate formiminohydrolase.
J Biol Chem. 1971 May 25;246(10):3320-9 PMID: 4930059
Isolation of the lac repressor.
Proc Natl Acad Sci U S A. 1966 Dec;56(6):1891-8 PMID: 16591435
Genetic and metabolic control of histidase and urocanase in Salmonella typhimurium, strain 15-59.
J Biol Chem. 1969 Oct 10;244(19):5392-402 PMID: 4899018
THE NON-INDUCIBILITY OF REPRESSOR FORMATION.
J Mol Biol. 1965 Jun;12:328-30 PMID: 14337496
Genetic control of histidine degradation in Salmonella typhimurium, strain LT-2.
J Biol Chem. 1969 Oct 10;244(19):5382-91 PMID: 4899017

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.7.1493

Published

1971-07-00

Pages

1493-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389225

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.7.1493 PMC Full Text View journal details

Analysis Services

Nature and self-regulated synthesis of the repressor of the hut operons in Salmonella typhimurium.

Contact

WeChat Official Account