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PMID: 416163 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Protection against group B meningococcal disease. II. Infection and resulting immunity in a guinea pig model.

The Journal of experimental medicine ·Vol. 147 ·No. 3 ·1978-03-01 ·Pages 619-28

Frasch CE, Robbins JD

Abstract

A guinea pig subcutaneous chamber model was used to evaluate the specificity of the immune response resulting from Neisseria meningitidis infection. Small numbers of meningococci easily infected the chambers. The infections persisted for 6-8 days with relatively high levels of organisms (10(5)-10(6)/milliliter) in the chambers, and were then rapidly eliminated and no organisms could be cultured beyond day 14. Clearance of infection correlated with appearance of circulating antibody. Antibody against both the protein serotype antigen and the capsular polysaccharide were induced as a result of meningococcal infection. The group-specific polysaccharide response peaked 2-3 wk after the animals were inoculated, while the type-specific protein response peaked at 5-6 wk. The animals were quite resistant to reinfection with either the homologous serogroup or serotype.

MeSH Terms
Animals Antibodies, Bacterial/biosynthesis Disease Models, Animal Guinea Pigs Immunity Immunologic Memory Meningococcal Infections/immunology,microbiology Neisseria meningitidis/immunology Polysaccharides, Bacterial/immunology Serotyping
Chemicals
Antibodies, Bacterial Polysaccharides, Bacterial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Frasch C E
Robbins J D
References (28)
28 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.147.3.619
Published
1978-03-01
Pages
619-28
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2184191
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.147.3.619 PMC Full Text View journal details
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