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PMID: 4208531 Published · ppublish English Comparative Study Journal Article

Suppression of growth of Ehrlich ascites tumor cells in mice by trehalose-6,6'-dimycolate (cord factor) and BCG.

Infection and immunity ·Vol. 9 ·No. 6 ·1974-06-00 ·Pages 977-84

Yarkoni E, Wang L, Bekierkunst A

Abstract

Growth of Ehrlich ascites tumor cells in mice pretreated with cord factor was compared to growth of the tumor cells after pretreatment with Calmette-Guérin bacilli. Growth of Ehrlich ascites cells was strongly inhibited in the peritoneal cavities of mice pretreated with 80 mug of cord factor. The median survival time of the animals was prolonged (70 versus 17 days), and 40% of the mice survived more than 90 days. Tumor suppression was still detectable 36 days after administration of cord factor. The effect of cord factor was local. Comparable results were obtained with living or killed Calmette-Guérin bacilli. The results are discussed.

MeSH Terms
Animals Carcinoma, Ehrlich Tumor/drug therapy,therapy Disaccharides/therapeutic use Glycolipids/therapeutic use Injections, Intraperitoneal Injections, Intravenous Mice Mycobacterium tuberculosis Time Factors Trehalose/therapeutic use
Chemicals
Disaccharides Glycolipids Trehalose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yarkoni E
Wang L
Bekierkunst A
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31 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.9.6.977-984.1974
Published
1974-06-00
Pages
977-84
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414920
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.9.6.977-984.1974 PMC Full Text View journal details
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