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PMID: 4276350 Published · ppublish English Journal Article

Further study on neutralization of biochemical activity of cord factor by anti-cord factor antibody.

Infection and immunity ·Vol. 10 ·No. 1 ·1974-07-00 ·Pages 277-9

Kato M

Abstract

The action of trehalose-6, 6'-dimycolate (cord factor) of Mycobacterium tuberculosis to induce site II-specific inhibition of mitochondrial oxidative phosphorylation and to stimulate adenosine triphosphatase activity was neutralized by its specific antibody. The activity was restored after dissociation of cord factor from the immune complex.

MeSH Terms
Adenosine Triphosphatases/metabolism Animals Antibodies, Bacterial Antigen-Antibody Complex Electron Transport Malates/metabolism Mice Mitochondria, Liver/metabolism Mycobacterium tuberculosis/analysis Neutralization Tests Oxidative Phosphorylation/drug effects Pyruvates/metabolism Rotenone/metabolism Succinates/metabolism
Chemicals
Antibodies, Bacterial Antigen-Antibody Complex Malates Pyruvates Succinates Rotenone Adenosine Triphosphatases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kato M
References (8)
8 references, click to expand
  1. Studies of a biochemical lesion in experimental tuberculosis in mice. VII. Structural and functional damage in mouse liver mitochondria under the toxic action of cord factor.
    Am Rev Respir Dis. 1968 Aug;98(2):260-9 PMID: 4970047
  2. Studies on the chemistry of the cord factor of Mycobacterium tuberculosis.
    J Biol Chem. 1955 May;214(1):251-65 PMID: 14367384
  3. Studies of a biochemical lesion in experimental tuberculosis in mice. 8. Effect of derivatives and chemical analogues of cord factor on structure and function of mouse liver mitochondria.
    Am Rev Respir Dis. 1968 Oct;98(4):668-76 PMID: 5677154
  4. The serum proteins in multiple myelomatosis.
    Biochem J. 1940 Sep;34(8-9):1248-57 PMID: 16747310
  5. Site of action of lipid A on mitochondria.
    J Bacteriol. 1972 Oct;112(1):268-75 PMID: 4263402
  6. Site II-specific inhibition of mitochondria oxidative phosphorylation by trehalose-6,6'-dimycolate (cord factor) of Mycobacterium tuberculosis.
    Arch Biochem Biophys. 1970 Oct;140(2):379-90 PMID: 4319595
  7. Chemical structure and biochemical activity of cord factor analogs. 6,6'-Dimycoloyl sucrose and methyl 6-mycoloyl- -D-glucoside.
    Eur J Biochem. 1971 Oct 14;22(3):364-70 PMID: 4331058
  8. Isolation and biochemical activities of trehalose-6-monomycolate of Mycobacterium tuberculosis.
    Infect Immun. 1974 Jan;9(1):8-14 PMID: 4271721
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.10.1.277-279.1974
Published
1974-07-00
Pages
277-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414989
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.10.1.277-279.1974 PMC Full Text View journal details
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