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PMID: 4302187 Published · ppublish English Comparative Study Journal Article

Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro.

Journal of virology ·Vol. 2 ·No. 9 ·1968-09-00 ·Pages 878-85

De Somer P, De Clercq E, Billiau A, Schonne E, Claesen M

Abstract

Polyacrylic acid (PAA) and polymethacrylic acid (PMAA) were investigated for their antiviral properties in tissue culture. Compared to other related polyanions, as dextran sulfate, polystyrene sulfonate, polyvinyl sulfate, and polyphloroglucinol phosphate, PAA and PMAA were found to be significantly more antivirally active and less cytotoxic. PMAA added 24 hr prior to virus inoculation inhibited viral growth most efficiently but it was still effective when added 3 hr after infection. Neither a direct irreversible action on the virus nor inhibition of virus penetration into the cell could explain the antiviral activity of PMAA. PMAA inhibited the adsorption of the virus to the host cell and suppressed the one-cycle viral synthesis in tissue cultures inoculated with infectious RNA.

MeSH Terms
Acrylates/pharmacology Adsorption Antineoplastic Agents/pharmacology Antiviral Agents/pharmacology Arboviruses/growth & development Culture Techniques Dextrans/pharmacology Phloroglucinol/pharmacology Phosphates Poliovirus/growth & development Polystyrenes/pharmacology Polyvinyls/pharmacology Sulfates Sulfonic Acids Virus Replication/drug effects
Chemicals
Acrylates Antineoplastic Agents Antiviral Agents Dextrans Phosphates Polystyrenes Polyvinyls Sulfates Sulfonic Acids Phloroglucinol
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
De Somer P
De Clercq E
Billiau A
Schonne E
Claesen M
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26 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.2.9.878-885.1968
Published
1968-09-00
Pages
878-85
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC375707
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.2.9.878-885.1968 PMC Full Text View journal details
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