Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.

Journal of virology ·Vol. 2 ·No. 9 ·1968-09-00 ·Pages 886-93

De Somer P, De Clercq E, Billiau A, Schonne E, Claesen M

Abstract

A marked virus-inhibiting potency is obtained in the serum after intraperitoneal injection of polyacrylic acid (PAA) and polymethacrylic acid (PMAA) in mice. Much higher antiviral levels were reached than for other related polymers including dextran sulfate, heparin, polyvinyl sulfate, pyran copolymer, polystyrene sulfonate, and macrodex. The broad antiviral action of PAA and PMAA was attributed both to a direct interference with the virus-cell interaction and the viral ribonucleic acid metabolism and to the formation of an interferon-like factor. Both polyanions differed in interferon-inducing ability: highest serum interferon titer was obtained 18 hr after the intraperitoneal injection of PAA. The mechanism of interferon production by PAA and PMAA is discussed. As described previously for Sindbis virus and endotoxin, the animals also became hyporeactive after injection of PAA.

MeSH Terms

Acrylates/administration & dosage,pharmacology Animals Antiviral Agents/pharmacology Cellulose Chemistry Techniques, Analytical Dextrans/pharmacology Heparin/pharmacology Injections, Intraperitoneal Interferons/biosynthesis,blood Mice Polystyrenes/pharmacology Polyvinyls/pharmacology Pyrans/pharmacology RNA, Viral/metabolism Sulfates Sulfonic Acids Time Factors

Chemicals

Acrylates Antiviral Agents Dextrans Polystyrenes Polyvinyls Pyrans RNA, Viral Sulfates Sulfonic Acids Cellulose Heparin Interferons

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

De Somer P

De Clercq E

Billiau A

Schonne E

Claesen M

References (27)

27 references, click to expand

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes.
Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004-10 PMID: 5233831
Tolerance to the induction of interferons by endotoxin and virus: role of a humoral factor.
Proc Soc Exp Biol Med. 1965 Aug-Sep;119(4):1227-32 PMID: 5836039
Induction of circulating interferon by synthetic anionic polymers of known composition.
Nature. 1967 Apr 22;214(5086):416-7 PMID: 6032855
Influence of inhibitors of protein synthesis on interferon formation in mice.
Virology. 1965 Dec;27(4):541-50 PMID: 5855570
An interferon like substance induced by mannans.
Acta Virol. 1967 May;11(3):264-6 PMID: 4382481
Preparation of endotoxin.
Nature. 1966 Jan 1;209(5018):80 PMID: 5332605
Interferon appearance stimulated by endotoxin, bacteria, or viruses in mice pre-treated with Escherichia coli endotoxin or infected with Mycobacterium tuberculosis.
Nature. 1965 Oct 30;208(5009):456-8 PMID: 4956238
INTERFERON PRODUCTION INDUCED BY STATOLON.
Proc Natl Acad Sci U S A. 1964 Sep;52:741-4 PMID: 14212551
EFFECT OF ACTINOMYCIN D ON VIRUS AND ENDOTOXIN-INDUCED INTERFERONLIKE INHIBITORS IN RABBITS.
Proc Natl Acad Sci U S A. 1965 Jan;53:220-4 PMID: 14283202
THE SYNTHESIS AND CHROMATOGRAPHIC OF CARBOXYL CELLULOSE.
J Chromatogr. 1965 Jan;17:149-56 PMID: 14285542
In vitro and in vivo antiviral action of an interferon-like substance induced by Toxoplasma gondii.
Proc Soc Exp Biol Med. 1966 Dec;123(3):862-6 PMID: 4289528
Inducers of interferon and host resistance. 3. Double-stranded RNA from reovirus type 3 virions (reo 3-RNA).
Proc Natl Acad Sci U S A. 1967 Oct;58(4):1719-22 PMID: 4295834
Characteristics of interferon induced in vitro and in vivo by a TRIC agent.
Proc Soc Exp Biol Med. 1966 Jun;122(2):421-4 PMID: 4292459
Inducers of interferon and host resistance, IV. Double-stranded replicative form RNA (MS2-Ff-RNA) from E. coli infected with MS2 coliphage.
Proc Natl Acad Sci U S A. 1967 Nov;58(5):2102-8 PMID: 4295588
Interferon production by the spleen of rats after intravenous injection of Sindbis virus or heat-killed Escherichia coli.
Arch Gesamte Virusforsch. 1966;19(2):143-54 PMID: 4860822
INTERFERON-LIKE VIRAL INHIBITOR IN RABBITS AFTER INTRAVENOUS ADMINISTRATION OF ENDOTOXIN.
Science. 1964 Dec 11;146(3650):1472-4 PMID: 14208574
Induction of interferon in mice infected with Toxoplasma gondii.
Proc Soc Exp Biol Med. 1966 Dec;123(3):859-62 PMID: 4289527
An antiviral substance from Penicillium funiculosum. V. Induction of interferon by helenine.
J Exp Med. 1966 Apr 1;123(4):577-84 PMID: 5933468
Properties of rat-tumor interferon.
Biochim Biophys Acta. 1966 Feb 28;115(2):429-39 PMID: 5943444
Antiviral activity of polyacrylic and polymethacrylic acids. I. Mode of action in vitro.
J Virol. 1968 Sep;2(9):878-85 PMID: 4302187
A new method for preparation of agaraose for gel electrophoresis.
Biochim Biophys Acta. 1962 Aug 27;62:445-9 PMID: 14036248
Virus-like particles of a fraction of statolon, a mould product.
Nature. 1967 Aug 5;215(5101):649-50 PMID: 6050227
INTERFERON REDUCTION IN CHICKENS INJECTED WITH BRUCELLA ABORTUS.
Science. 1964 May 22;144(3621):1022-3 PMID: 14137938
Viruses in fungi and interferon stimulation.
Nature. 1968 May 11;218(5141):542-5 PMID: 4967851
Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin.
Science. 1965 Jul 16;149(3681):310-1 PMID: 17533668
Inducers of interferon and host resistance. I. Double-stranded RNA from extracts of Penicillium funiculosum.
Proc Natl Acad Sci U S A. 1967 Aug;58(2):782-9 PMID: 5233474
PATTERNS OF INTERFERON APPEARANCE IN MICE INFECTED WITH BACTERIA OR BACTERIAL ENDOTOXIN.
Nature. 1964 Nov 14;204:712 PMID: 14236314

Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.2.9.886-893.1968

Published

1968-09-00

Pages

886-93

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375708

Subset

External Links

PubMed source DOI: 10.1128/JVI.2.9.886-893.1968 PMC Full Text View journal details

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Antiviral activity of polyacrylic and polymethacrylic acids. II. Mode of action in vivo.

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