Early events in herpes simplex virus infection: a radioautographic study.

Journal of virology ·Vol. 4 ·No. 1 ·1969-07-00 ·Pages 67-74

Hummeler K, Tomassini N, Zajac B

Abstract

The early events in herpes simplex virus infection were studied by means of radio-autography. The virus was rapidly taken up by the host cells and uncoated. Viral deoxyribonucleic acid (DNA) reached the nuclear sites of replication in 15 to 30 min after infection. The viral DNA occasionally associated with chromosomes or condensed chromatin but was more frequently found to be randomly distributed. Viral progeny appeared 3 hr after infection. These particles did not show any particular spatial relationship to the parental DNA. The morphological latent period lasted 2.5 hr.

MeSH Terms

Animals Autoradiography Cell Line Cell Nucleus Cricetinae Kidney Microscopy, Electron Simplexvirus/metabolism Thymidine/metabolism Tritium Virus Replication

Chemicals

Tritium Thymidine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hummeler K

Tomassini N

Zajac B

References (12)

12 references, click to expand

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AN ELECTRON MICROSCOPE STUDY OF THE ATTACHMENT AND PENETRATION OF HERPES VIRUS IN BHK21 CELLS.
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.4.1.67-74.1969

Published

1969-07-00

Pages

67-74

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC375839

Subset

External Links

PubMed source DOI: 10.1128/JVI.4.1.67-74.1969 PMC Full Text View journal details

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