Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 67 ·No. 4 ·1970-12-00 ·Pages 1797-803

Hanafusa T, Hanafusa H, Miyamoto T

Abstract

Cells derived from the majority of chick embryos, although free of presently known avian tumor virus particles, appear to contain genetic materials similar to those found in this virus group. After infection of these cells with avian leukosis or Rous sarcoma virus, the genetic factor was recovered by incorporation into mature infectious virus. The newly isolated virus (RAV-60) did not require the assistance of another virus for its replication. The virus had most of the attributes of an RNA-containing avian leukosis virus, and its outer structure resembled the Rous sarcoma virus known as RSV(0).

MeSH Terms

Alpharetrovirus/isolation & purification Animals Avian Leukosis Virus/pathogenicity Avian Sarcoma Viruses/pathogenicity Chick Embryo/cytology,microbiology Culture Techniques Cytopathogenic Effect, Viral Helper Viruses Viral Interference

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hanafusa T

Hanafusa H

Miyamoto T

References (11)

11 references, click to expand

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Murine sarcoma virus (Harvey): characteristics of focus formation in mouse embryo cell cultures, and virus production by hamster tumor cells.
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J Gen Virol. 1968 Dec;3(3):379-91 PMID: 4304102
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Characteristics of two new avian tumor virus subgroups.
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Recovery of a hamster-specific, focus-forming, and sarcomagenic virus from a "noninfectious" hamster tumor induced by the Kirsten Mouse sarcoma virus.
J Natl Cancer Inst. 1969 Oct;43(4):925-34 PMID: 4310099
A type of chick embryo cell that fails to support formation of infectious RSV.
Virology. 1970 Jan;40(1):55-64 PMID: 4312375
Hamster-tropic sarcomagenic and nonsarcomagenic viruses derived from hamster tumors induced by the Gross pseudotype of Moloney sarcoma virus.
Proc Natl Acad Sci U S A. 1970 Feb;65(2):310-7 PMID: 4984233
A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus.
Proc Natl Acad Sci U S A. 1970 Jun;66(2):314-21 PMID: 4317912
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.67.4.1797

Published

1970-12-00

Pages

1797-803

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC283429

Subset

External Links

PubMed source DOI: 10.1073/pnas.67.4.1797 PMC Full Text View journal details

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Recovery of a new virus from apparently normal chick cells by infection with avian tumor viruses.

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