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PMID: 43292 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effects of heat-stable enterotoxin of Yersinia enterocolitica on ion transport and cyclic guanosine 3',5'-monophosphate metabolism in rabbit ileum.

Infection and immunity ·Vol. 26 ·No. 3 ·1979-12-00 ·Pages 875-8

Rao MC, Guandalini S, Laird WJ, Field M

Abstract

Strains of Yersinia enterocolitica produce a heat-stable enterotoxin which is positive in the suckling mouse bioassay. Partial purification by a procedure previously worked out for heat-stable Escherichia coli enterotoxin yielded a substance which increases particulate guanylate cyclase activity and short-circuit current and inhibits active Cl-absorption in rabbit ileal mucosa. These effects of Y. enterocolitica enterotoxin are similar to those of heat-stable E. coli enterotoxin, suggesting a common mechanism of action.

MeSH Terms
Animals Chlorides/metabolism Cyclic GMP/metabolism Electrophysiology Enterotoxins/pharmacology Guanylate Cyclase/metabolism Ileum/enzymology,metabolism,physiology In Vitro Techniques Male Rabbits Yersinia
Chemicals
Chlorides Enterotoxins Guanylate Cyclase Cyclic GMP
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rao M C
Guandalini S
Laird W J
Field M
References (11)
11 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.26.3.875-878.1979
Published
1979-12-00
Pages
875-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC414701
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.26.3.875-878.1979 PMC Full Text View journal details
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