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PMID: 4332013 Published · ppublish English Journal Article

Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 12 ·1971-12-00 ·Pages 3190-4

Taylor BA, Meier H, Myers DD

Abstract

Genetic studies were aimed at elucidation of the mechanism of inheritance of the group-specific antigen of the murine leukemia virus. Two approaches have been used. First, a classical Mendelian hybridization experiment was performed with mice of the high-leukemia AKR strain and the low-leukemia C57L strain; the first filial (F(1)) generation hybrids, the second filial (F(2)) generation hybrids, and the backcrosses to the two parental strains. Second, a number of partially inbred lines derived from the F(2) generation of the same cross were used. The results of these studies demonstrate a specific genetic regulation of expression of group-specific antigens. Genes permissive to the expression of the antigen are dominant or semidominant to their nonpermissive alleles. It appears that two dominant genes carried by the AKR strain, but not by the C57L strain, are necessary for the presence of a complete virus; one of these controls the expression of group-specific antigen.

MeSH Terms
Animals Antigens Antigens, Viral Complement Fixation Tests Crosses, Genetic Embryo, Mammalian/immunology Female Genes, Dominant Genetic Linkage Guinea Pigs Hybridization, Genetic Immune Sera Leukemia Virus, Murine/immunology Male Mice Mice, Inbred Strains Rats Recombination, Genetic Species Specificity Spleen/immunology Virus Replication
Chemicals
Antigens Antigens, Viral Immune Sera
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Taylor B A
Meier H
Myers D D
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30 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.68.12.3190
Published
1971-12-00
Pages
3190-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC389619
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.68.12.3190 PMC Full Text View journal details
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