An attempt at an analysis of the factors determining the time course of the end-plate current. I. The effects of prostigmine and of the ratio of Mg 2+ to Ca 2+ .
1. An attempt was made to analyse the factors which might determine the time course of the falling phase of the end-plate current.2. The end-plate current was measured by ;clamping' the membrane potential during neuromuscular transmission.3. The falling phase of the end-plate current was found to consist of a non-exponential, and an exponential portion, the duration of both of which varies under different experimental conditions.4. The results suggest that the rate constants determining the dissociation of the receptor-mediator complex seem greatly to influence the time course of the end-plate current.
19 references, click to expand
-
A dual effect of calcium ions on neuromuscular facilitation.J Physiol. 1968 Mar;195(2):471-80 PMID: 4296698
-
A kinetic model for the action of xylocaine on receptors for acetylcholine.J Gen Physiol. 1968 Jul;52(1):162-80 PMID: 4316946
-
The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.J Physiol. 1957 Oct 30;138(3):434-44 PMID: 13481883
-
An analysis of the end-plate potential recorded with an intracellular electrode.J Physiol. 1951 Nov 28;115(3):320-70 PMID: 14898516
-
Analysis of sodium and potassium conductances in the procaine end-plate potential.J Physiol. 1966 Apr;183(3):592-606 PMID: 5919558
-
An electrophysiological approach to drug-receptor mechanisms.Comp Biochem Physiol. 1969 Sep 15;30(6):997-1017 PMID: 4900204
-
Statistical factors involved in neuromuscular facilitation and depression.J Physiol. 1954 Jun 28;124(3):574-85 PMID: 13175200
-
Actions of anti-cholinesterases on endplate potential of frog muscle.J Neurophysiol. 1949 Jan;12(1):59-80 PMID: 18122899
-
The antagonism of Ca2+ by Na+ and other monovalent ions at the frog neuromuscular junction.Q J Exp Physiol Cogn Med Sci. 1968 Jul;53(3):239-49 PMID: 5188311
-
A study of the end-plate potential in sodium deficient solution.J Physiol. 1968 Sep;198(1):81-90 PMID: 5677033
-
The effect of atropine on the frog sartorius neuromuscular junction.J Physiol. 1968 Mar;195(2):493-503 PMID: 5647334
-
Interaction between sodium and calcium ions in the process of transmitter release at the neuromuscular junction.J Physiol. 1968 Sep;198(1):203-18 PMID: 16992314
-
THE EFFECT OF CALCIUM ON ACETYLCHOLINE RELEASE FROM MOTOR NERVE TERMINALS.Proc R Soc Lond B Biol Sci. 1965 Feb 16;161:496-503 PMID: 14278410
-
Hyperpolarization of mammalian motor nerve terminals.J Physiol. 1962 Aug;163:115-37 PMID: 14449605
-
Post-tetanic restoration of neuromuscular transmission blocked by D-tubocurarine.J Physiol. 1952 Oct;118(2):216-27 PMID: 13000706
-
Active phase of frog's end-plate potential.J Neurophysiol. 1959 Jul;22(4):395-411 PMID: 13673292
-
An attempt at an analysis of the factors determining the time course of the end-plate current. II. Temperature.J Physiol. 1972 Jul;224(2):333-48 PMID: 4341937
-
Alteration by xylocaine (lidocaine) and its derivatives of the time course of the end plate potential.J Gen Physiol. 1968 Jul;52(1):144-61 PMID: 4316945
-
Effect of prostigmine on the time course of the end-plate potential in the rat diaphragm.J Physiol. 1971 Mar;213(3):533-44 PMID: 5551401
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
