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PMID: 4364543 Published · ppublish English Journal Article

A molecular model of high density lipoproteins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 4 ·1974-04-00 ·Pages 1534-8

Assmann G, Brewer HB

Abstract

Based on the analysis of recombined lipidapoprotein complexes by C-13 and P-31 nuclear magnetic resonance spectroscopy and circular dichroism [Assmann, G., Sokoloski, E. A. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, 549-553; Assmann, G., Highet, R. J., Sokoloski, E. A. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, in press; Assmann, G. & Brewer, H. B., Jr. (1974) Proc. Nat. Acad. Sci. USA 71, 989-993] and the identification of conformational amphipathic regions in apoproteins, a new model for human high density lipoproteins is proposed. This model is analogous to membrane models proposed by Singer, in that protein "icebergs" are embedded in a "sea" of lipid.

MeSH Terms
Amino Acid Sequence Apoproteins Circular Dichroism Lipoproteins, HDL Magnetic Resonance Spectroscopy Models, Structural Protein Conformation
Chemicals
Apoproteins Lipoproteins, HDL
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Assmann G
Brewer H B
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.4.1534
Published
1974-04-00
Pages
1534-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC388265
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.4.1534 PMC Full Text View journal details
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