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PMID: 4364897 Published · ppublish English Journal Article

Harvey sarcoma virus: a second murine type C sarcoma virus with rat genetic information.

Journal of virology ·Vol. 13 ·No. 6 ·1974-06-00 ·Pages 1211-9

Scolnick EM, Parks WP

Abstract

The nucleic acid sequences found in the Harvey strain of murine sarcoma virus have been analyzed by RNA.[(3)H]DNA and [(3)H]RNA.DNA hybridization techniques. The Harvey strain of murine sarcoma virus has been found to possess at least two sets of nucleic acid sequences. One set of sequences is contained in the Moloney strain of mouse type-C virus, and the other set is contained in DNA transcripts synthesized in endogenous reactions containing rat type-C virus(es). The nucleic acid sequences that are detected in the Harvey sarcoma virus with the DNA probes synthesized from the rat type-C virus(es) are related to the rat sequences detected in the Kirsten strain of murine sarcoma virus. The results support the model that both Kirsten and Harvey sarcoma viruses arose through a process of recombination or reassortment between mouse type-C viruses and sequences in rat cells and suggest that the information for transformation of fibroblasts may be contained in the rat type-C or cellular genome.

MeSH Terms
Animals Base Sequence Cell Transformation, Neoplastic Cells, Cultured DNA, Viral/analysis Gammaretrovirus/analysis Kidney Mice Nucleic Acid Hybridization RNA, Viral/analysis Rats Retroviridae/analysis Tritium
Chemicals
DNA, Viral RNA, Viral Tritium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Scolnick E M
Parks W P
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.13.6.1211-1219.1974
Published
1974-06-00
Pages
1211-9
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC355440
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.13.6.1211-1219.1974 PMC Full Text View journal details
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