Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 68 ·No. 9 ·1971-09-00 ·Pages 2165-8

Gilman AG, Nirenberg M

Abstract

The effects of potential neurohormones on the intracellular concentrations of adenosine 3':5'-cyclic monophosphate have been examined with three clonal lines of cultured glial tumors. In all cases, norepinephrine and isoproterenol produced striking elevations of the intracellular concentrations of the cyclic nucleotide. The response was mediated by a beta-adrenergic receptor. This effect is hypothesized to represent a molecular mechanism for neuronal-glial communication coupled to concurrent communication between neurons.

MeSH Terms

Adrenergic alpha-Antagonists/pharmacology Adrenergic beta-Antagonists/pharmacology Aminobutyrates/pharmacology Animals Astrocytoma/metabolism Carbachol/pharmacology Catecholamines/pharmacology Cells, Cultured Clone Cells Cyclic AMP/metabolism Dopamine/pharmacology Glioma/metabolism Histamine/pharmacology Humans Isoproterenol/pharmacology Neurons/metabolism Norepinephrine/pharmacology Prostaglandins/pharmacology Rats Serotonin/pharmacology Theophylline/pharmacology Time Factors

Chemicals

Adrenergic alpha-Antagonists Adrenergic beta-Antagonists Aminobutyrates Catecholamines Prostaglandins Serotonin Histamine Carbachol Theophylline Cyclic AMP Isoproterenol Dopamine Norepinephrine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Gilman A G

Nirenberg M

References (11)

11 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.68.9.2165

Published

1971-09-00

Pages

2165-8

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC389376

Subset

External Links

PubMed source DOI: 10.1073/pnas.68.9.2165 PMC Full Text View journal details

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Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons.

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