Properties of a small transcribed poly A sequence in heterogeneous nuclear RNA of HeLa cells.
A class of heterogeneous nuclear RNA (hnRNA) molecules contain an internal transcribed poly A sequence of close to 25 uninterrupted AMP residues. HnRNA molecules containing this sequence are separable from those containing the large 3' terminal poly A sequence on the basis of their differential affinity for oligo dT cellulose. The fact that the transcribed small poly A and the 3' terminal poly A are not found in the same hnRNA molecules even though both are present in similar size classes and that the small poly A is absent from cytoplasmic messenger RNA (mRNA) has led us to propose a scheme for mRNA processing in which the 3' end of the small poly A in hnRNA becomes a priming size for the post-transcriptional addiction of the large poly A.
17 references, click to expand
-
AN IMPROVED PROCEDURE FOR MEASURING THE DISTRIBUTION OF P32O4--AMONG THE NUCLEOTIDES OF RIBONUCLEIC ACID.Anal Biochem. 1964 May;8:126-9 PMID: 14167265
-
Spliced segments at the 5' terminus of adenovirus 2 late mRNA.Proc Natl Acad Sci U S A. 1977 Aug;74(8):3171-5 PMID: 269380
-
Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing.Cell. 1978 Dec;15(4):1477-93 PMID: 729004
-
Characterization of the poly(adenylic acid) sequences in RNA synthesized in vitro by mouse myeloma nuclei.Biochemistry. 1978 Aug 8;17(16):3221-8 PMID: 687578
-
Two adenovirus mRNAs have a common 5' terminal leader sequence encoded at least 10 kb upstream from their main coding regions.Cell. 1977 Sep;12(1):9-21 PMID: 902321
-
An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.Cell. 1977 Sep;12(1):1-8 PMID: 902310
-
mRNAs containing and lacking poly (A) function as separate and distinct classes during embryonic development.Prog Nucleic Acid Res Mol Biol. 1976;19:119-22 PMID: 1032908
-
hnRNA in HeLa cells: distribution of transcript sizes estimated from nascent molecule profile.Cell. 1976 Nov;9(3):465-72 PMID: 991275
-
Poly(uridylic acid) sequences in messenger ribonucleic acid of HeLa cells.Biochemistry. 1976 Oct 19;15(21):4643-9 PMID: 974081
-
Polyadenylic acid segment in mRNA becomes shorter with age.Nat New Biol. 1973 Feb 28;241(113):265-8 PMID: 4511912
-
Purification of messenger RNA and heterogeneous nuclear RNA containing poly(a) sequences.Methods Enzymol. 1974;29:431-43 PMID: 4369093
-
Localization of the polyadenylate sequences in messenger ribonucleic acid and in the heterogeneous nuclear ribonucleic acid of HeLa cells.J Biol Chem. 1973 Feb 25;248(4):1472-6 PMID: 4346958
-
Differential metabolism of large and small poly(A) sequences in the heterogeneous nuclear RNA of HeLa cells.Proc Natl Acad Sci U S A. 1974 Jan;71(1):200-4 PMID: 4544010
-
Characterization of the poly(adenylic acid) regions and the adjacent nucleotides in heterogeneous nuclear ribonucleic acid and messenger ribonucleic acid from HeLa cells.Biochemistry. 1973 Jun 5;12(12):2324-30 PMID: 4710583
-
Polyadenylic acid sequences in E. coli messenger RNA.Nature. 1975 Jul 10;256(5513):144-6 PMID: 1097936
-
Molecular classes of heterogeneous nuclear RNA in sea urchin embryos.J Mol Biol. 1975 Jul 5;95(3):455-76 PMID: 1152062
-
The selective interruption of nucleolar RNA synthesis in HeLa cells by cordycepin.J Cell Biol. 1969 May;41(2):510-20 PMID: 5783871
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
