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PMID: 4480288 Published · ppublish English Comparative Study Journal Article

Effects of benzoctamine and chlordiazepoxide on turnover and uptake of 5-hydroxytryptamine in the brain.

British journal of pharmacology ·Vol. 51 ·No. 4 ·1974-08-00 ·Pages 571-5

Lippmann W, Pugsley TA

Abstract

1 Benzoctamine, a new psychoactive drug, known to exert in man an anti-anxiety effect resembling that of chlordiazepoxide, decreased the disappearance of intraventricularly-injected [(14)C]-5-hydroxytryptamine (5-HT) from rat brain, as did chlordiazepoxide.2 Both drugs partially inhibited the alpha-ethyl-3-hydroxy-4-methylphenylethylamine-induced depletion of rat brain 5-HT.3 It is concluded that benzoctamine, like chlordiazepoxide, decreases 5-HT turnover in the brain and that this action may play a role in the anti-anxiety effect of these drugs observed in man.

MeSH Terms
Animals Anthracenes/pharmacology Brain/metabolism Chlordiazepoxide/pharmacology Male Phenethylamines/pharmacology Rats Serotonin/metabolism Serotonin Antagonists
Chemicals
Anthracenes Phenethylamines Serotonin Antagonists Serotonin Chlordiazepoxide
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lippmann W
Pugsley T A
References (23)
23 references, click to expand
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Article Info
Journal
British journal of pharmacology
Abbr.
Br J Pharmacol
ISSN
0007-1188
DOI
10.1111/j.1476-5381.1974.tb09676.x
Published
1974-08-00
Pages
571-5
Language
English
Region
England
NLM ID
7502536
PMCID
PMC1778070
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1476-5381.1974.tb09676.x PMC Full Text View journal details
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