Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 70 ·No. 4 ·1973-04-00 ·Pages 1108-11

Snell GD, Cherry M, McKenzie IF, Bailey DW

Abstract

A new locus is described that determines an alloantigen on the surface of lymphocytes. It differs from loci previously described in that the corresponding antibody, at least in most antisera, reacts almost exclusively with node lymphocytes, and weakly or not at all with thymuslymphocytes. Positive strains include C57BL/6, C57BL/10, C57L, C57BR/cd, and RF; negative strains include BALB/c, C3H, and SJL. The symbol Ly-4 is assigned, with the C57BL/6 allele being Ly-4(b), and the BALB/c allele Ly-4(a).

MeSH Terms

Animals Antigen-Antibody Reactions Cell Membrane/immunology Chromosome Mapping Crosses, Genetic Cytotoxicity Tests, Immunologic Genes Genetic Linkage Hemagglutination Tests Histocompatibility Antigens Immunization Isoantigens Lymphocytes/immunology Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Mice, Inbred Strains Recombination, Genetic Spleen/immunology Submandibular Gland/immunology Thymus Gland/immunology

Chemicals

Histocompatibility Antigens Isoantigens

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Snell G D

Cherry M

McKenzie I F

Bailey D W

References (26)

26 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.70.4.1108

Published

1973-04-00

Pages

1108-11

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC433436

Subset

External Links

PubMed source DOI: 10.1073/pnas.70.4.1108 PMC Full Text View journal details

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Ly-4, a new locus determining a lymphocyte cell-surface alloantigen in mice.

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