Lack of a correlation between cell-mediated immunity to the carrier and the carrier-hapten helper effect.
The relationship between cell-mediated immunity to the carrier and the carrier-hapten helper effect was studied in the rat by using three forms of the carrier which differed in their capacity to induce carrier-specific delayed-type hypersensitivity. The three carriers were polymerized flagellin (POL), flagellin (FIN), and acetoacetylated flagellin (AFIN), which induced FIN-specific delayed-type hypersensitivity in the order AFIN > FIN > POL. Helper cells for the anti-DNP antibody responses to a range of DNP-FIN conjugates appeared to be almost inversely related to cell-mediated immunity to the carrier, being in the order POL > FIN =/> AFIN. These differences occurred whether the carriers were injected in saline or FCA, but were less pronounced with the heavily DNP-conjugated flagellins.
14 references, click to expand
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Preferential induction of cell-mediated immunity by chemically modified sheep erythrocytes.Eur J Immunol. 1972 Apr;2(2):143-51 PMID: 4566301
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Delayed hypersensitivity: is the same population of thymus-derived cells responsible for cellular immunity reactions and the carrier effect?Immunol Commun. 1972;1(3):289-99 PMID: 4123363
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Delayed-type hypersensitivity in the mouse. II. Transfer by thymus-derived (T) cells.Scand J Immunol. 1972;1(3):237-45 PMID: 4123996
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Delayed-type hypersensitivity in the mouse. 3. Inactivation of thymus-derived effector cells and their precursors.Scand J Immunol. 1972;1(3):247-53 PMID: 4541573
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Relationship of T cells involved in cell-mediated immunity and antibody synthesis.Nat New Biol. 1973 Jul 4;244(131):21-2 PMID: 4578425
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In vitro approaches to the mechanism of cell-mediated immune reactions.Adv Immunol. 1971;13:101-208 PMID: 4947653
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Regulation of the immune response. I. Differential effect of passively administered antibody on the thymus-derived and bone marrow-derived lymphocytes.J Exp Med. 1971 Sep 1;134(3 Pt 1):577-87 PMID: 15776562
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Influence of neonatal thymectomy on antibody production in the Lewis rat.Int Arch Allergy Appl Immunol. 1970;37(3):258-77 PMID: 5410920
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Immune response to chemically modified flagellin. I. Induction of antibody tolerance to flagellin by acetoacetylated derivatives of the protein.J Exp Med. 1971 Jul 1;134(1):1-20 PMID: 4997585
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The carrier effect in the secondary response to hapten-protein conjugates. 3. The anatomical distribution of helper cells and antibody-forming-cell-precursors.Eur J Immunol. 1971 Apr;1(2):63-5 PMID: 5166690
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The detection and production of macrophage cytophilic antibody to different antigens in different laboratory animals.Immunology. 1971 Dec;21(6):1045-58 PMID: 5129995
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Regulation of the immune response by antibody. I. Suppression of antibody formation and concomitant enhancement of cell-mediated immunity by passive antibody.Cell Immunol. 1972 May;4(1):66-85 PMID: 5016930
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