Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.

The Journal of experimental medicine ·Vol. 140 ·No. 5 ·1974-11-01 ·Pages 1432-7

Gottlieb PD

Abstract

The inbred and congenic strain distribution of the I(H)-peptide marker in the variable region of mouse immunoglobulin light chains has been compared with other known genetic markers. A positive correlation was noted between the I(H)-peptide marker and expression of the Ly-3.1 thymocyte cell surface antigen. This suggests that the locus responsible for I(H)-peptide expression is genetically linked to the Ly-2 and Ly-3 loci in linkage group XI on chromsome 6 of the mouse.

MeSH Terms

Animals Antigens Cell Membrane/immunology Chromosome Mapping Genes Genetic Linkage Immunoglobulin Fragments Mice Mice, Inbred Strains/immunology Peptides/analysis T-Lymphocytes/immunology

Chemicals

Antigens Immunoglobulin Fragments Peptides

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Gottlieb P D

References (10)

10 references, click to expand

Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.
Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(1019):175-93 PMID: 4385242
An approach to the mapping of antigens on the cell surface.
Proc Natl Acad Sci U S A. 1968 Jul;60(3):886-93 PMID: 5243930
A genetic marker in the variable region of light chains of mouse immunoglobulins.
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1192-9 PMID: 5274448
Ly-C: a third locus specifying alloantigens expressed only on thymocytes and lymphocytes.
Transplantation. 1971 Mar;11(3):351-3 PMID: 5558567
Antibody diversity.
Annu Rev Biochem. 1971;40:969-1012 PMID: 4942225
Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3190-4 PMID: 4332013
Genetic linkage relationships of loci specifying differentiation alloantigens in the mouse.
Transplantation. 1972 Mar;13(3):239-43 PMID: 5021438
Genetic control of the immune response. Mapping of the Ir-1 locus.
J Exp Med. 1972 Jun 1;135(6):1259-78 PMID: 4554451
List of congenic lines of mice. I. Lines with differences at alloantigen loci.
Transplantation. 1973 Jan;15(1):137-53 PMID: 4711011
The genetic control of immunoglobulin synthesis.
Annu Rev Genet. 1972;6:1-46 PMID: 4124595

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.140.5.1432

Published

1974-11-01

Pages

1432-7

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139733

Subset

External Links

PubMed source DOI: 10.1084/jem.140.5.1432 PMC Full Text View journal details

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Genetic correlation of a mouse light chain variable region marker with a thymocyte surface antigen.

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