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PMID: 4564156 Published · ppublish English Journal Article

Specific macrophage immunity to vaccinia virus: macrophage-virus interaction.

Infection and immunity ·Vol. 6 ·No. 1 ·1972-07-00 ·Pages 9-16

Avila FR, Schultz RM, Tompkins WA

Abstract

Macrophage immunity to vaccinia virus was examined by measuring replication of vaccinia virus in immune and nonimmune rabbit peritoneal macrophages. Vaccinia virus multiplied in macrophages from normal rabbits but failed to replicate in macrophages from immune rabbits. The specificity of vaccinia restriction was demonstrated by the ability of myxoma virus to replicate in nonimmune and vaccinia-immune macrophages. Vaccinia virus absorbed equally well to immune and nonimmune macrophages, but only a small fraction of immune cells supported synthesis of virus antigen. Virus eclipse and infective center neutralization studies suggested that much of the virus remained at the plasma membrane of immune macrophages, even after prolonged incubation in culture. These data support our previous suggestions that macrophages may contribute to specific immunity against vaccinia virus.

MeSH Terms
Adsorption Animals Cells, Cultured Cross Reactions Cytopathogenic Effect, Viral Fluorescent Antibody Technique Guinea Pigs/immunology Immunity, Cellular Immunization Kidney Macrophages/immunology Myxoma virus/immunology Neutralization Tests Peritoneum/immunology Rabbits Trypsin Vaccinia virus/immunology,isolation & purification Virus Replication
Chemicals
Trypsin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Avila F R
Schultz R M
Tompkins W A
References (19)
19 references, click to expand
  1. Cellular immunity in vitro: migration inhibition and phagocytosis.
    Infect Immun. 1971 Dec;4(6):697-702 PMID: 4949509
  2. ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES.
    Bacteriol Rev. 1964 Mar;28:30-71 PMID: 14127970
  3. Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice.
    J Immunol. 1970 May;104(5):1155-9 PMID: 4315460
  4. In vitro assessment of cellular immunity to vaccinia virus: contribution of lymphocytes and macrophages.
    Infect Immun. 1970 Dec;2(6):783-90 PMID: 16557917
  5. EFFECT OF IMMUNIZATION ON TISSUE SUSCEPTIBILITY TO VACCINIA VIRUS IN VITRO.
    Virology. 1963 Nov;21:402-10 PMID: 14081365
  6. An in vitro measure of cellular immunity to fibroma virus.
    J Immunol. 1970 Feb;104(2):502-10 PMID: 4904883
  7. The function of macrophages in the immune response.
    Semin Hematol. 1970 Apr;7(2):225-48 PMID: 4910220
  8. Macrophages and age-dependent resistance to Herpes simplex virus in mice.
    J Immunol. 1970 May;104(5):1160-5 PMID: 4315461
  9. Characterization of surface antigen on cells infected by fibroma virus.
    J Immunol. 1970 Nov;105(5):1181-9 PMID: 4321290
  10. GROWTH OF VIRULENT AND ATTENUATED ECTROMELIA VIRUS IN CULTURED MACROPHAGES FROM NORMAL AND ECTROMELIAIMMUNE MICE.
    J Immunol. 1964 Jun;92:837-42 PMID: 14210788
  11. Lymphoid Cells in Delayed Hypersensitivity II. In Vitro Phagocytosis and Cellular Immunity.
    Infect Immun. 1971 Apr;3(4):548-52 PMID: 16558015
  12. INTERACTION OF VACCINIA VIRUS AND CELLS IN PRIMARY AND CONTINUOUS CULTURE.
    Nature. 1963 Sep 14;199:1117-8 PMID: 14066970
  13. Persistence of antigen on the surface of macrophages.
    Nature. 1969 Jun 21;222(5199):1193-5 PMID: 5788993
  14. Restriction of herpes simplex virus by macrophages. An analysis of the cell-virus interaction.
    J Exp Med. 1971 Jan 1;133(1):19-38 PMID: 4321913
  15. Leukocytes and interferon in the host response to viral infections. II. Enhanced interferon response of leukocytes from immune animals.
    J Bacteriol. 1966 Jun;91(6):2185-91 PMID: 5943935
  16. Macrophages and viral immunity.
    Semin Hematol. 1970 Apr;7(2):185-214 PMID: 4317324
  17. The monocyte in cellular immunity.
    Semin Hematol. 1970 Apr;7(2):172-84 PMID: 4986255
  18. Mechanisms of recovery from a generalized viral infection: mousepox. I. The effects of anti-thymocyte serum.
    J Exp Med. 1970 Nov;132(5):1035-54 PMID: 4319373
  19. Cell-mediated immune responses to virus infections and virus-induced tumours.
    Br Med Bull. 1967 Jan;23(1):60-5 PMID: 5342382
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.6.1.9-16.1972
Published
1972-07-00
Pages
9-16
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC422482
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.6.1.9-16.1972 PMC Full Text View journal details
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