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PMID: 4612525 Published · ppublish English Journal Article

Mitochondrial genetics in Bakers' yeast: a molecular mechanism for recombinational polarity and suppressiveness.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 71 ·No. 11 ·1974-11-00 ·Pages 4612-6

Perlman PS, Birky CW

Abstract

Recombinational polarity and suppressiveness are two well-known but puzzling cytoplasmic genetic phenomena in bakers' yeast, Saccharomyces cerevisiae. Little progress has been made in characterizing the underlying molecular mechanisms of these phenomena. In this paper we describe a molecular model for recombinational polarity that is compatible with the available genetic evidence. The model stresses the role of small deletions and excision/repair processes in otherwise canonical recombinational events. According to the model, both phenomena require recombination and may share mechanistic elements.

MeSH Terms
Crosses, Genetic DNA, Mitochondrial/metabolism Extrachromosomal Inheritance Genotype Models, Biological Recombination, Genetic Saccharomyces cerevisiae/metabolism Suppression, Genetic
Chemicals
DNA, Mitochondrial
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Perlman P S
Birky C W
References (28)
28 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.71.11.4612
Published
1974-11-00
Pages
4612-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC433938
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.71.11.4612 PMC Full Text View journal details
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