Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.

The Journal of experimental medicine ·Vol. 136 ·No. 4 ·1972-10-01 ·Pages 715-21

Mond JJ, Takahashi T, Thorbecke GJ

Abstract

Spleen cells from LAF(1) mice hyperimmune to sheep erythrocytes (SE) lost their ability to transfer a secondary response to irradiated recipients after incubation with anti-theta and rabbit complement in vitro. Small numbers of specific immune cells even when taken 3 days after a primary SE injection reconstituted the direct and indirect plaque-forming cell responses. Larger numbers of cells sensitized to B. abortus (or keyhole limpet hemocyanin), and given together with the corresponding antigen, also partially reconstituted the ability to respond to SE. This property was mediated by theta-bearing cells and was interpreted as due to a nonspecific humoral factor liberated by specifically activated T cells and acting on B cell proliferation or maturation.

MeSH Terms

Animals Antibody Formation Antigens, Heterophile Bone Marrow/immunology Bone Marrow Cells Brucella abortus/immunology Complement System Proteins Cytotoxicity Tests, Immunologic Endotoxins Erythrocytes/immunology Escherichia coli/immunology Hemagglutination Tests Hemocyanins Hemolytic Plaque Technique Immune Sera Immunity, Maternally-Acquired Immunization, Passive Immunologic Memory Mercaptoethanol/pharmacology Mice Radiation Chimera Sheep/immunology Spleen/cytology,immunology Thymus Gland/immunology

Chemicals

Antigens, Heterophile Endotoxins Immune Sera Mercaptoethanol Complement System Proteins Hemocyanins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Mond J J

Takahashi T

Thorbecke G J

References (27)

27 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.136.4.715

Published

1972-10-01

Pages

715-21

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2139276

Subset

External Links

PubMed source DOI: 10.1084/jem.136.4.715 PMC Full Text View journal details

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Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.

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