Interaction between doxycycline and barbiturates.

British medical journal ·Vol. 1 ·No. 5907 ·1974-03-23 ·Pages 535-6

Neuvonen PJ, Penttilä O

Abstract

In a cross-over study of five hospitalized patients the half life of doxycycline was significantly shortened after 10 days' treatment with phenobarbitone. In five patients on continuous barbiturate therapy the half life of doxycycline was even shorter. Barbiturates or other agents inducing drug metabolism should be used cautiously in combination with doxycycline, since this might result in therapeutically inadequate serum concentrations of the antibiotic.

MeSH Terms

Adult Aged Amobarbital/pharmacology Barbiturates/pharmacology Carbamazepine/pharmacology Doxycycline/administration & dosage,blood,metabolism Drug Interactions Enzyme Induction Female Half-Life Humans Male Middle Aged Pentobarbital/pharmacology Phenobarbital/administration & dosage,pharmacology Phenytoin/pharmacology

Chemicals

Barbiturates Carbamazepine Phenytoin Amobarbital Pentobarbital Doxycycline Phenobarbital

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Neuvonen P J

Penttilä O

References (5)

5 references, click to expand

Simplified, accurate method for antibiotic assay of clinical specimens.
Appl Microbiol. 1966 Mar;14(2):170-7 PMID: 4959982
Interference of iron with the absorption of tetracyclines in man.
Br Med J. 1970 Nov 28;4(5734):532-4 PMID: 5483323
Clinical implications of enzyme induction.
Ann N Y Acad Sci. 1971 Jul 6;179:421-31 PMID: 5285387
Clinically important drug interactions.
Drugs. 1973;5(3):161-86 PMID: 4576570
Dose-dependent enzyme induction.
Clin Pharmacol Ther. 1973 Jul-Aug;14(4):514-20 PMID: 4723259

Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.5907.535

Published

1974-03-23

Pages

535-6

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1633645

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.5907.535 PMC Full Text

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