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PMID: 5129270 Published · ppublish English Journal Article

Exchange of sterols between myelin and other membranes of developing rat brain.

The Biochemical journal ·Vol. 122 ·No. 5 ·1971-05-00 ·Pages 751-8

Banik NL, Davison AN

Abstract

1. The effect of inhibition of cholesterol synthesis by a hypocholesterolaemic drug (AY-9944) was studied in rat brain during development. 2. At 2 weeks after administration of AY-9944 to young rats 7-dehydrocholesterol accounted for half the total sterol of myelin and other subcellular components. 3. At 4 weeks after injection of the drug 7-dehydrocholesterol had disappeared whereas the cholesterol content of myelin had increased by an equivalent amount. Our studies show that purified myelin has low 7-dehydrocholesterol reductase activity and suggest that 7-dehydrocholesterol is largely converted into cholesterol outside the myelin sheath. 4. Resultant cholesterol may be re-incorporated into myelin by an exchange process. 5. The metabolism of sterols in developing brain is discussed.

MeSH Terms
Acetates/metabolism Animals Brain/growth & development,metabolism Carbon Isotopes Cholesterol/analysis,biosynthesis Chromatography, Gas Cyclohexanes Female Male Microsomes/analysis Mitochondria/analysis Myelin Sheath/analysis,metabolism Rats Sterols/analysis,metabolism
Chemicals
Acetates Carbon Isotopes Cyclohexanes Sterols Cholesterol
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Banik N L
Davison A N
References (32)
32 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1220751
Published
1971-05-00
Pages
751-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1176844
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1220751 PMC Full Text View journal details
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