The preferential codon usages in variable and constant regions of immunoglobulin genes are quite distinct from each other.
The pattern of codon utilization in the variable and constant regions of immunoglobulin genes are compared. It is shown that, in these regions, codon utilizations are quite distinct from one another: For most degenerate codons, there is a selective bias that prefers C and/or G ending codons to U and/or A ending codons in the constant region compared with the bias in the variable region. This would strongly suggest that, in immunoglobulin genes, the bias in code word usage is determined by other factors than those concerning with the translational mechanism such as tRNA availability and codon-anticodon interaction. A possibility is also suggested that this differance of code word usage between them is due to the existence of secondary structure in the constant region but not in the variable region.
18 references, click to expand
-
Codons and nearest-neighbor nucleotide pairs in mammalian messenger RNA.J Mol Evol. 1978 Jun 20;11(2):121-7 PMID: 671560
-
Pattern and chance in the use of the genetic code.J Mol Evol. 1978 Feb 21;10(4):319-23 PMID: 344896
-
Nucleotide sequence of the ribosomal protein gene cluster adjacent to the gene for RNA polymerase subunit beta in Escherichia coli.Proc Natl Acad Sci U S A. 1979 Apr;76(4):1697-701 PMID: 377281
-
Viral, prokaryote and eukaryote genes contrasted by mRNA sequence indexes.FEBS Lett. 1978 Nov 1;95(1):1-11 PMID: 214340
-
Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex.Proc Natl Acad Sci U S A. 1979 Apr;76(4):1663-7 PMID: 156363
-
Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain.Nucleic Acids Res. 1979 Jul 25;6(10):3305-21 PMID: 113776
-
Sequences of mouse immunoglobulin light chain genes before and after somatic changes.Cell. 1978 Dec;15(4):1133-44 PMID: 103630
-
Complete sequence of constant and 3' noncoding regions of an immunoglobulin mRNA using the dideoxynucleotide method of RNA sequencing.Cell. 1978 Nov;15(3):1067-75 PMID: 103625
-
A complete immunoglobulin gene is created by somatic recombination.Cell. 1978 Sep;15(1):1-14 PMID: 100225
-
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segments.Nature. 1979 Feb 22;277(5698):627-33 PMID: 106304
-
On codon usage.Nature. 1979 Jan 25;277(5694):328 PMID: 368645
-
Bacteriophage MS2 RNA: a correlation between the stability of the codon: anticodon interaction and the choice of code words.J Mol Evol. 1978 Dec 29;12(2):113-9 PMID: 368346
-
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.Proc Natl Acad Sci U S A. 1978 Aug;75(8):3881-5 PMID: 279004
-
Is there selection against wobble in codon-anticodon pairing?Science. 1976 Dec 10;194(4270):1173-4 PMID: 996548
-
Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein.Nature. 1972 May 12;237(5350):82-8 PMID: 4555447
-
The large extent of putative secondary nucleic acid structure in random nucleotide sequences or amino acid derived messenger-RNA.J Mol Evol. 1974;3(4):279-91 PMID: 4416342
-
A-protein gene of bacteriophage MS2.Nature. 1975 Jul 24;256(5515):273-8 PMID: 806810
-
Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene.Nature. 1976 Apr 8;260(5551):500-7 PMID: 1264203
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