Home LiteratureArticle Details
PMID: 5263025 Published · ppublish English Journal Article

Cells involved in the immune response. 13. The nature of the cellular interactions relating antibody formation and immunologic tolerance: a unified hypothesis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 64 ·No. 1 ·1969-09-00 ·Pages 75-80

Richter M

Abstract

The various cells and cell pathways involved in the induction of the primary humoral immune response have been discussed from the point of view of the unitary, as opposed to the multiple, pathway concept. The immunocompetent cells made unresponsive in the immunologically tolerant animal and the cells capable of responding with antibody formation were considered. It is concluded that there exist multiple cellular pathways through which the humoral immune response may be expressed.

MeSH Terms
Animals Antibody Formation Bone Marrow/immunology Bone Marrow Cells Immune Tolerance Lymphocytes/immunology Macrophages/immunology Models, Biological
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Richter M
References (24)
24 references, click to expand
  1. Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.
    J Exp Med. 1969 Jun 1;129(6):1261-73 PMID: 4890861
  2. The histophysiology of the antibody response. I. Histogenesis of the plasma cell reaction in rabbit spleen.
    Lab Invest. 1963 Jan;12:106-18 PMID: 13928647
  3. Studies on the immune reconstitution of sublethally irradiated mice by peritoneal macrophages.
    Immunology. 1968 Dec;15(6):827-35 PMID: 4884963
  4. Cell to cell interaction in the immune response. I. Hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes.
    J Exp Med. 1968 Oct 1;128(4):801-20 PMID: 5691985
  5. The coexistence of antibody with antigen during immunological paralysis to BSA.
    Immunology. 1966 Dec;11(6):571-88 PMID: 5954774
  6. A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.
    Proc Natl Acad Sci U S A. 1968 Oct;61(2):542-7 PMID: 16591704
  7. The X-Y-Z scheme of immunocyte maturation. 3. Early IgM memory and the nature of the memory cell.
    J Immunol. 1967 Apr;98(4):836-43 PMID: 4164560
  8. The kinetics of immune tolerance to human serum albumin induced in sublethally x-irradiated rabbits.
    Immunology. 1968 Sep;15(3):343-55 PMID: 5681592
  9. The carriage of immunological memory by small lymphocytes in the rat.
    J Exp Med. 1966 Nov 1;124(5):1017-30 PMID: 5926297
  10. Macrophages from tolerant rabbits as mediators of a specific immunological response in vitro.
    Immunology. 1967 Feb;12(2):159-63 PMID: 6020119
  11. Role of the thymus and other central lymphoid tissues in immunological disease.
    Annu Rev Med. 1967;18:113-38 PMID: 4164731
  12. The role of macrophages in the induction of antibody in x-irradiated animals.
    Immunology. 1967 Feb;12(2):197-206 PMID: 6020122
  13. Immunocompetence of transferred thymus-marrow cell combinations.
    J Immunol. 1966 Dec;97(6):828-32 PMID: 5333748
  14. Ultrastructural localization of antibody in differentiating plasma cells.
    J Exp Med. 1968 Jan 1;127(1):109-18 PMID: 5635036
  15. Immune paralysis of thymus cells by bovine serum albumin.
    Nature. 1968 Nov 9;220(5167):611 PMID: 4301109
  16. Role of macrophages in antibody production. Immune response to sheep red blood cells.
    J Immunol. 1967 Oct;99(4):744-50 PMID: 6051391
  17. Studies on macrophage RNA involved in antibody production.
    Proc Natl Acad Sci U S A. 1967 Jun;57(6):1849-56 PMID: 5231416
  18. The immunogenic capacity of antigen taken up by peritoneal exudate cells.
    Immunology. 1969 Jan;16(1):1-14 PMID: 5770808
  19. THE MECHANISM OF TOLERANCE PRODUCED IN RATS TO SHEEP ERYTHROCYTES. I. PLAQUE-FORMING CELL AND ANTIBODY RESPONSE TO SINGLE AND MULTIPLE INJECTIONS OF ANTIGEN.
    J Exp Med. 1965 May 1;121:671-81 PMID: 14278224
  20. Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells.
    J Exp Med. 1969 Apr 1;129(4):757-74 PMID: 5766947
  21. The immune response of mice to antigen in macrophages.
    Immunology. 1968 Aug;15(2):287-96 PMID: 5673285
  22. Cells involved in the immune response. XI. Identification of the antigen-reactive cell as the tolerant cell in the immunologically tolerant rabbit.
    J Exp Med. 1969 Jul 1;130(1):165-84 PMID: 4183777
  23. Studies on the radiosensitive phase of the primary antibody response in rabbits. I. The role of the macrophage.
    J Immunol. 1967 Feb;98(2):225-9 PMID: 4163834
  24. Cells involved in the immune response. IV. The response of normal and immune rabbit bone marrow and lymphoid tissue lymphocytes to antigens in vitro.
    J Exp Med. 1968 Nov 1;128(5):1099-128 PMID: 4176224
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.64.1.75
Published
1969-09-00
Pages
75-80
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC286128
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.64.1.75 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2