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PMID: 52849 Published · ppublish English Journal Article

Prostaglandin, slow-reacting substance, and histamine release from anaphylactic guinea-pig hearts, and its pharmacological modification.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 289 ·No. 1 ·1975-00-00 ·Pages 65-76

Liebig R, Bernauer W, Peskar BA

Abstract

Prostaglandins (Pgs), slow-reacting substance of anaphylaxis (SRS-A), and histamine were released from anaphylactic isolated perfused guinea pig hearts. Pgs were to the greatest part of the F2alpha-type. PgE2 was found in traces only. Neither PgA2, nor the metabolites 13,14-dihydro-15-keto-PgF2alpha and 13,14-dihydro-15-keto-PgE2 were detected in the perfusates. Isoproterenol reduced the PgF2alpha output significantly. This effect was increased by the addition of theophylline. Propranolol did not reverse the effect of isoproterenol, but in a high concentration (5 mug/ml) reduced the PgF2alpha output for its own. Indomethacin completely abolished the anaphylactic prostaglandin release. The histamine liberation was significantly decreased only by the combination of isoproterenol and theophylline, and also by a high concentration of propranolol (5 mug/ml). In contrast to the Pg release, the anaphylactic SRS-A and histamine liberation was not abolished by indomethacin, but rather increased. The results are discussed in view of the possible role of the released substances in the functional events of cardiac anaphylaxis.

MeSH Terms
Anaphylaxis/metabolism Animals Coronary Circulation/drug effects Female Guinea Pigs Heart Rate/drug effects Histamine Release/drug effects In Vitro Techniques Isoproterenol/pharmacology Male Myocardial Contraction/drug effects Myocardium/metabolism Papillary Muscles/metabolism Propranolol/pharmacology Prostaglandins/metabolism Prostaglandins A/metabolism Prostaglandins E/metabolism Prostaglandins F/metabolism SRS-A/metabolism Theophylline/pharmacology
Chemicals
Prostaglandins Prostaglandins A Prostaglandins E Prostaglandins F SRS-A Propranolol Theophylline Isoproterenol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Liebig R
Bernauer W
Peskar B A
References (36)
36 references, click to expand
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Article Info
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Abbr.
Naunyn Schmiedebergs Arch Pharmacol
ISSN
0028-1298
DOI
10.1007/BF00498030
Published
1975-00-00
Pages
65-76
Language
English
Region
Germany
NLM ID
0326264
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00498030 View journal details
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