Inhibitory effect of passive antibody on active immunity induced against rabies by vaccination.

Bulletin of the World Health Organization ·Vol. 45 ·No. 6 ·1971-00-00 ·Pages 747-53

Wiktor TJ, Lerner RA, Koprowski H

Abstract

The administration of rabies-immune serum in addition to regular vaccination has been recommended as routine treatment in man after severe exposure to rabies virus. The inhibitory effect of passive antibody on active immunity induced against rabies by vaccination was investigated in rabbits. It was demonstrated that a dose of rabies-immune serum could completely block the neutralizing antibody response engendered by a very potent rabies vaccine. The inhibitory effect could be partially overcome if the number of vaccine doses was increased, if vaccination was started 15 days after serum administration, or if immune serum was given 12-24 hours after vaccination. Even under these circumstances, the antibody level was lower than that observed after administration of vaccine alone. Both 19S and 7S antibody exerted similar effects.

MeSH Terms

Animals Antibody Formation Female Immune Sera/administration & dosage Immunity, Active Immunity, Maternally-Acquired Male Neutralization Tests Rabbits Rabies/immunology Rabies Vaccines Vaccination

Chemicals

Immune Sera Rabies Vaccines

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Wiktor T J

Lerner R A

Koprowski H

References (15)

15 references, click to expand

Human rabies after antiserum and vaccine postexposure treatment. Case report and review.
Ann Intern Med. 1966 Jun;64(6):1297-302 PMID: 5948985
Competition of 19S and 7S antigen receptors in the regulation of the primary immune response.
J Exp Med. 1968 Jul 1;128(1):133-52 PMID: 5662011
Effects of homologous or heterologous antiserum on neutralizing-antibody response to rabies vaccine.
Bull World Health Organ. 1968;39(3):407-17 PMID: 5303907
Purification of rabies virus grown in tissue culture.
J Virol. 1968 Aug;2(8):836-49 PMID: 4973571
Evaluation of human rabies immune globulin and homologous and heterologous antibody.
J Immunol. 1969 May;102(5):1314-21 PMID: 4181550
Immunogenicity of concentrated and purified rabies vaccine of tissue culture origin.
Proc Soc Exp Biol Med. 1969 Jul;131(3):799-805 PMID: 5791793
Human rabies encephalitis in Vietnam.
Ann Intern Med. 1970 Mar;72(3):375-8 PMID: 4906112
Reproducible plaquing system for rabies, lymphocytic choriomeningitis,k and other ribonucleic acid viruses in BHK-21-13S agarose suspensions.
J Virol. 1967 Dec;1(6):1224-6 PMID: 4987176
Antigenic and immunogenic properties of components contained in rabies virus-infected tissue culture fluids.
J Immunol. 1970 Aug;105(2):291-8 PMID: 5433693
Effective protection of monkeys against death from street virus by post-exposure administration of tissue-culture rabies vaccine.
Bull World Health Organ. 1971;45(1):1-11 PMID: 5004004
Studies on chick-embryo-adapted rabies virus. V. Protection of animals with antiserum and living attenuated virus after exposure to street strain of rabies virus.
J Immunol. 1954 Jan;72(1):85-93 PMID: 13118195
Antibody formation. I. The suppression of antibody formation by passively administered antibody.
J Exp Med. 1961 May 1;113:935-57 PMID: 13779027
CULTIVATION OF RABIES VIRUS IN HUMAN DIPLOID CELL STRAIN WI-38.
J Immunol. 1964 Sep;93:353-66 PMID: 14218592
Use of hyperimmune anti-rabies serum concentrates in experimental rabies.
Am J Med. 1950 Apr;8(4):412-20 PMID: 15410721
[Field trials with rabies vaccine on persons bitten by rabid wolves].
Bull World Health Organ. 1955;13(5):747-72 PMID: 13284556

Article Info

Journal

Bulletin of the World Health Organization

Abbr.

Bull World Health Organ

ISSN

0042-9686

Published

1971-00-00

Pages

747-53

Language

English

Region

Switzerland

NLM ID

7507052

PMCID

PMC2427995

Subset

External Links

PubMed source PMC Full Text View journal details

Analysis Services

Inhibitory effect of passive antibody on active immunity induced against rabies by vaccination.

Contact

WeChat Official Account