Home LiteratureArticle Details
PMID: 53257 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies.

The Journal of experimental medicine ·Vol. 142 ·No. 5 ·1975-11-01 ·Pages 1121-32

Trenkner E, Riblet R

Abstract

Anti-idiotypic antibodies have been used to mimic antigen in the mouse antiphosphorylcholine response in order to investigate the induction of precursors of antibody-forming cells. We have shown that interaction of anti-idiotype antibody with receptor antibody molecules induces the formation of antibodies that are specific for phosphorylcholine and carry the idiotypic determinants. This induction is dependent on the recognition of carrier determinants on the anti-idiotype antibody by helper T cells. We conclude that receptor antibody molecules on the surface of the precursors of antibody-forming cells deliver the antigenic signal for the induction of these cells.

MeSH Terms
Animals Antibodies, Anti-Idiotypic Antibody Formation Antibody Specificity Antibody-Producing Cells/immunology Binding Sites, Antibody Cells, Cultured Choline/analogs & derivatives Epitopes Immunoglobulins/immunology Mice Mice, Inbred Strains Phosphorylcholine/immunology Spleen/immunology T-Lymphocytes/immunology
Chemicals
Antibodies, Anti-Idiotypic Epitopes Immunoglobulins Phosphorylcholine Choline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Trenkner E
Riblet R
References (21)
21 references, click to expand
  1. Common individual antigenic determinants in five of eight BALB-c IgA myeloma proteins that bind phosphoryl choline.
    J Exp Med. 1970 Oct 1;132(4):737-51 PMID: 4101363
  2. Genetics of the antibody response to dextran in mice.
    Science. 1972 Jul 14;177(4044):178-80 PMID: 4114394
  3. Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine.
    Eur J Immunol. 1972 Aug;2(4):319-26 PMID: 4117282
  4. Clonal nature of the immune response to phosphorylcholine. I. Specificity, class, and idiotype of phosphorylcholine-binding receptors on lymphoid cells.
    J Exp Med. 1974 Jan 1;139(1):58-73 PMID: 4128448
  5. The control of humoral and associative antibody synthesis.
    Transplant Rev. 1972;11:217-67 PMID: 4129422
  6. Immunoglobulin structure: amino terminal sequences of mouse myeloma proteins that bind phosphorylcholine.
    Science. 1974 Mar 8;183(4128):962-6 PMID: 4129807
  7. Genetics of a new IgVH (T15 idiotype) marker in the mouse regulating natural antibody to phosphorylcholine.
    J Exp Med. 1974 Apr 1;139(4):983-1001 PMID: 4131516
  8. Isolation of antigen-binding cells from unprimed mice: demonstration of antibody-forming cell precursor activity and correlation between precursor and secreted antibody avidities.
    J Exp Med. 1974 Oct 1;140(4):904-20 PMID: 4139227
  9. Membrane immunoglobulins and antigen receptors on B and T lymphocytes.
    Adv Immunol. 1974;19(0):67-216 PMID: 4139885
  10. Towards a network theory of the immune system.
    Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89 PMID: 4142565
  11. Clonal nature of the immune response to phosphorylcholine. II. Idiotypic specificity and binding characteristics of anti-phosphorylcholine antibodies.
    J Immunol. 1974 May;112(5):1747-56 PMID: 4150447
  12. The use of allogeneic T lymphocytes and bacterial lipopolysaccharide to induce immune responses to monovalent haptens in vitro.
    J Immunol. 1974 Sep;113(3):918-24 PMID: 4153527
  13. Genetics of immunoglobulins in the mouse.
    Adv Immunol. 1967;7:91-145 PMID: 4172218
  14. A theory of self-nonself discrimination.
    Science. 1970 Sep 11;169(3950):1042-9 PMID: 4194660
  15. Specific suppression of the antibody response by antibodies to receptors.
    Proc Natl Acad Sci U S A. 1972 Sep;69(9):2701-5 PMID: 4403565
  16. Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype.
    Eur J Immunol. 1974 Apr;4(4):296-302 PMID: 4546826
  17. Suppression of idiotypic specificities in adult mice by administration of antiidiotypic antibody.
    J Exp Med. 1972 Jun 1;135(6):1293-300 PMID: 4623607
  18. The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis.
    J Exp Med. 1973 Sep 1;138(3):699-714 PMID: 4737981
  19. Separation of normal and immune lymphoid cells by antigen-coated coated columns. Antigen-binding characteristics of membrane antibodies as analyzed by hapten-protein antigens.
    J Exp Med. 1970 Jul 1;132(1):110-26 PMID: 4927594
  20. Immunocompetence of transferred thymus-marrow cell combinations.
    J Immunol. 1966 Dec;97(6):828-32 PMID: 5333748
  21. Cell populations and cell proliferation in the in vitro response of normal mouse spleen to heterologous erythrocytes. Analysis by the hot pulse technique.
    J Exp Med. 1967 Sep 1;126(3):443-54 PMID: 6034750
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.142.5.1121
Published
1975-11-01
Pages
1121-32
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2189971
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.142.5.1121 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2