The role of shikimic acid in the biosynthesis of vitamin K2.

The Biochemical journal ·Vol. 100 ·No. 1 ·1966-07-00 ·Pages 1-6

Cox GB, Gibson F

Abstract

1. Shikimic acid was shown to be a precursor of vitamin K(2) (MK-8) in Escherichia coli. 2. The benzene ring of the naphthaquinone arises from shikimic acid. 3. The methyl group of methionine is incorporated into vitamin K(2). 4. A scheme relating the biosynthesis of vitamin K(2) and ubiquinone to the general pathway of aromatic biosynthesis is proposed.

MeSH Terms

Acetates/metabolism Carbon Isotopes Chemical Phenomena Chemistry Chromatography Chromatography, Thin Layer Escherichia coli/metabolism Methionine/metabolism Quinones Shikimic Acid/pharmacology Spectrum Analysis Vitamin K/biosynthesis

Chemicals

Acetates Carbon Isotopes Quinones Vitamin K Shikimic Acid Methionine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Cox G B

Gibson F

References (13)

13 references, click to expand

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BIOSYNTHESIS OF A VITAMIN K2 BY CELL-FREE EXTRACTS OF MYCOBACTERIUM PHLEI.
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THE BIOSYNTHESIS OF THE BENZOQUINONE RING OF UBIQUINONE FROM P-HYDROXYBENZALDEHYDE AND P-HYDROXYBENZOIC ACID IN RAT KIDNEY, AZOTOBACTER VINELANDII, AND BAKER'S YEAST.
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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1000001

Published

1966-07-00

Pages

1-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1265084

Subset

External Links

PubMed source DOI: 10.1042/bj1000001 PMC Full Text View journal details

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The role of shikimic acid in the biosynthesis of vitamin K2.

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