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PMID: 5637150 Published · ppublish English Journal Article

Disproportional synthesis of the adult duck's two hemoglobins during acute anemia.

The Journal of clinical investigation ·Vol. 47 ·No. 3 ·1968-03-00 ·Pages 679-89

Bertles JF, Borgese TA

Abstract

Concurrent synthesis of two or more hemoglobins occurs in normal man, the human hemoglobinopathies, and certain animal species. Duck erythrocytes produced in response to acutely induced anemic hypoxia (hemolysis or blood loss) contained reciprocally altered proportions of Hb I (alpha(2) (I) beta(2) (I)) and Hb II (alpha(2) (II) beta(2) (II)); the relative proportion of Hb II was 50-100% increased. Relative rates of synthesis of the two hemoglobins remained proportional to their new concentrations throughout erythroid maturation. This information favors the proposal that relatively increased activity, not delayed decay, of biosynthetic processes responsible for net synthesis of Hb II had occurred. These studies support the concept that the individual biosyntheses of multiple hemoglobins, presumably under genetic control, are potentially manipulable, and they provide evidence for one mechanism leading in a reproducible fashion to alterations in net synthesis in vivo.

MeSH Terms
Acetates Acute Disease Amino Acids/metabolism Anemia/chemically induced,metabolism Anemia, Hemolytic/metabolism Animals Blood Cell Count Carbon Isotopes Centrifugation Ducks Electrophoresis Erythrocytes/cytology,metabolism Hematocrit Hemoglobins/biosynthesis Hemorrhage/metabolism In Vitro Techniques Iron/metabolism Phenylhydrazines
Chemicals
Acetates Amino Acids Carbon Isotopes Hemoglobins Phenylhydrazines Iron
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bertles J F
Borgese T A
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38 references, click to expand
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI105763
Published
1968-03-00
Pages
679-89
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC297213
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI105763 PMC Full Text View journal details
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