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PMID: 5726197 Published · ppublish English Journal Article

The metabolism of [Me-14C]choline in the brain of the rat in vivo.

The Biochemical journal ·Vol. 110 ·No. 2 ·1968-11-00 ·Pages 201-6

Ansell GB, Spanner S

Abstract

[Me-(14)C]Choline was injected intracerebrally into the adult rat, and its uptake into the lipids and their water-soluble precursors in brain was studied. The radioactivity could be detected only in the choline-containing lipids and was confined to the base choline. The results indicated that initial phosphorylation of the free choline followed by the formation of CDP-choline and the subsequent transfer of the phosphorylcholine to a diglyceride is one of the principal routes by which choline lipids in brain are formed. Further evidence for this was obtained in experiments in which either phosphoryl[Me-(14)C]choline or [(32)P]orthophosphate was injected and the radioactivity in the choline-containing water-soluble and lipidbound components studied.

MeSH Terms
Animals Brain/metabolism Carbon Isotopes Choline/metabolism Injections Phosphates/metabolism Phosphatidylcholines/biosynthesis Phospholipids/biosynthesis Phosphorus Isotopes Rats
Chemicals
Carbon Isotopes Phosphates Phosphatidylcholines Phospholipids Phosphorus Isotopes Choline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Ansell G B
Spanner S
References (22)
22 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1100201
Published
1968-11-00
Pages
201-6
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1187198
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1100201 PMC Full Text View journal details
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