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PMID: 5749225 Published · ppublish English Journal Article

Changes in the ribonucleic acid metabolism of aging mouse tissues with particular reference to the prostate gland.

The Biochemical journal ·Vol. 110 ·No. 1 ·1968-11-00 ·Pages 79-86

Mainwaring WI

Abstract

1. The synthesis of RNA in purified nuclei of tissues from aged mice is substantially diminished. 2. As judged by the recovery of RNA in 105000g supernatants of tissue homogenates, the synthesis of ribosomal RNA may be particularly affected. 3. The decrease in RNA synthesis may be due to changes in the composition of the nuclear-associated protein with age, which result in changes in the priming ability of tissue chromatin. 4. Aging is accompanied by marked changes in the sedimentation profiles of ribonucleoprotein particles. These can be attributed to an age-associated depletion in messenger RNA or to an increased susceptibility to enzymic disaggregation.

MeSH Terms
Aging Animals Cell Nucleus/metabolism Centrifugation, Density Gradient Liver/metabolism Lung/metabolism Male Mice Prostate/metabolism RNA/biosynthesis,metabolism RNA, Transfer/metabolism Ribosomes/metabolism Tritium
Chemicals
Tritium RNA RNA, Transfer
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Mainwaring W I
References (34)
34 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1100079
Published
1968-11-00
Pages
79-86
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1187111
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1100079 PMC Full Text View journal details
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